Metastatic Pancreatic Adenocarcinoma (PRINCE Trial, Nat Med. 2022) - iAtlas Harmonized

Summary

Metastatic Pancreatic Adenocarcinoma (PRINCE Trial, Nat Med. 2022) - iAtlas Harmonized is a study catalogued by cBioPortal DataHub under the cancer-type code paad. EvidenceHelix groups it with pancreas studies.

Study description

Whole-exome sequencing and neoantigen landscape analysis of 93 metastatic pancreatic adenocarcinomas and their matched normals from a randomized phase 2 trial evaluating the efficacy of nivolumab and/or sotigalimab with gemcitabine/nab-paclitaxel (chemotherapy) as first-line therapy for metastatic pancreatic cancer. The reprocessing of raw sequencing data is coordinated by CRI iAtlas (https://cri-iatlas.org/).

Text as published in the source's study metadata.

Citation & PubMed

Padron et al. Nat Med. 2022

Linked PubMed records: PMID 35662283

Source & licence

Metadata from cBioPortal DataHub at e1b75cd25b, available under the ODC Open Database License (ODbL) 1.0. See the Source metadata tab for every field.

Source metadata

Study identifier

paad_iatlas_prince_2022

Short name

not given

Source cancer-type code

paad

Reference genome

hg38

Source access groups

not given

Original study

View on cBioPortal

Metadata file

meta_study.txt at e1b75cd25b

Database licence

ODC Open Database License (ODbL) 1.0

Study-level metadata only (title, description, cancer-type code, citation, PubMed ids). No patient, sample, mutation or clinical data, and no publication full text, is included. Individual studies may carry their own terms; follow each study's source links before reusing its data.

Citations

Padron et al. Nat Med. 2022

• PubMed record 35662283 ↗

Citation counts are not part of the source metadata and are not shown.

Related studies

• Pancreatic Adenocarcinoma (ICGC, Nature 2012)

  Whole-exome sequencing of 99 pancreatic samples and their matched normals.

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• Pancreatic Adenocarcinoma (QCMG, Nature 2016)

  Whole-genome and deep-exome sequencing analysis of 456 pancreatic ductal adenocarcinomas

  PancreasOther published and consortium studiesSource code paadPubMed 1

• Pancreatic Cancer (UTSW, Nat Commun 2015)

  Whole exome sequencing of 109 micro-dissected pancreatic cancer cases and normal control tissue.

  PancreasOther published and consortium studiesSource code paadPubMed 1

• Pancreatic Ductal Adenocarcinoma (CPTAC, Cell 2021)

  Whole-genome sequencing (WGS) and whole-exome sequencing (WES) of 140 pancreatic cancers with 67 normal adjacent tissues. Proteogenomic characterization generated by CPTAC.

  PancreasOther published and consortium studiesSource code paadPubMed 1

• Pancreatic Adenocarcinoma (TCGA, Firehose Legacy)

  TCGA Pancreatic Adenocarcinoma. Source data from GDAC Firehose (http://gdac.broadinstitute.org/runs/stddata__2016_01_28/data/PAAD/20160128/). Previously known as TCGA Provisional.

  PancreasTCGA Firehose LegacySource code paad

• Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)

  Pancreatic Adenocarcinoma TCGA PanCancer data. The original data is here (https://gdc.cancer.gov/about-data/publications/pancanatlas). The publications are here (https://www.cell.com/pb-assets/consortium/pancanceratla…

  PancreasTCGA PanCancer AtlasSource code paadPubMed 12

• Acinar Cell Carcinoma of the Pancreas (JHU, J Pathol 2014)

  Whole exome sequencing of 23 surgically resected pancreatic carcinomas with acinar differentiation and their matched normals.

  PancreasOther published and consortium studiesSource code paacPubMed 1

• Cystic Tumor of the Pancreas (Johns Hopkins, PNAS 2011)

  Whole-exome sequencing of major neoplastic cyst types of the pancreas: 8 serous cystadenomas (SCAs), 8 intraductal papillary mucinous neoplasms (IPMNs), 8 mucinous cystic neoplasms (MCNs), and 8 solid pseudopapillary…

  PancreasOther published and consortium studiesSource code pactPubMed 1

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