We thank all of the trial participants and the health-care, pharmacy and prison staff at HMP YOI Isis and HM YOI Polmont, as well as pharmacy staff at Forth Valley Royal Hospital, and the staff at King’s Health Partners Clinical Trial Office and the King's Clinical Trial Unit.
Philip Asherson is supported by the National Institute for Health and Care Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London, and by a NIHR Senior Investigator award (NF-SI-0616-10040).
Research teams
A huge thank you to all the fantastic research staff who have worked with us over the years: Craig Marsh, Megan Bedding, Laura Giannulli, Megan Mansfield, Caroline Kelly, Lauren Wilson, Clare McCafferty, Grace Williamson, Khuram Khan, Donnie McPherson, Sharon Jakobowitz, Lydia Carter-Mackie and Prajakta Patil.
Contributions of authors
Philip Asherson (https://orcid.org/0000-0003-2667-2254) (Chief Investigator) had overall responsibility for the trial design and trial management.
Lena Johansson (https://orcid.org/0000-0002-4473-1134) (Clinical Trial Manager) co-ordinated the implementation of the trial and day-to-day management, and contributed to the interpretation of the trial findings.
Rachel Holland (https://orcid.org/0000-0002-8630-2821) (Trial Statistician) developed the SAP, prepared DMC reports, completed all analyses and contributed to the interpretation of the trial findings.
Megan Bedding (https://orcid.org/0000-0002-5256-0021) (Research Worker) contributed to data collection, was a TMG member and contributed to the the interpretation of the trial findings.
Andrew Forrester (https://orcid.org/0000-0003-2510-1249) (Co-applicant) contributed to the design and interpretation of the trial findings, and dissemination activities.
Laura Giannulli (https://orcid.org/0000-0002-4182-1820) (Research Worker) contributed to data collection, was a TMG member and contributed to the interpretation of the trial findings.
Ylva Ginsberg (https://orcid.org/0000-0003-1934-376X) (TSC member) contributed to the interpretation of the trial and writing of the final report.
Sheila Howitt (https://orcid.org/0000-0002-2489-2440) (Co-applicant, Research Psychiatrist) contributed to the design, data collection and interpretation of the trial findings.
Imogen Kretzschmar (https://orcid.org/0000-0002-4615-7754) (Research Psychiatrist) was a TMG member and contributed to data collection and the interpretation of the trial findings.
Stephen Lawrie (https://orcid.org/0000-0002-2444-5675) (Co-applicant) contributed to the design and interpretation of the trial findings.
Craig Marsh (https://orcid.org/0000-0003-2149-8189) (Research Psychiatrist), Caroline Kelly (https://orcid.org/0000-0003-4349-5915) (Research Worker), Megan Mansfield (https://orcid.org/0000-0003-2896-3119) (Research Worker), Clare McCafferty (https://orcid.org/0000-0002-3633-2686) (Research Nurse) and Khuram Khan (Research Psychiatrist) contributed to data collection, were TMG members and contributed to the interpretation of the trial findings.
Ulrich Müller-Sedgwick (https://orcid.org/0000-0002-5499-4077) (TSC member) contributed to the interpretation of the trial findings.
John Strang (https://orcid.org/0000-0002-5413-2725) (Co-applicant) contributed to the design and interpretation of the trial findings.
Grace Williamson (https://orcid.org/0000-0002-4618-5819) (Research Placement Student) and Lauren Wilson (https://orcid.org/0000-0001-8817-6788) (Research Placement Student) contributed to data collection, were TMG members and contributed to the interpretation of the trial findings.
Susan Young (https://orcid.org/0000-0002-8494-6949) (Co-applicant) contributed to the design and interpretation of the trial findings and dissemination activities.
Sabine Landau (https://orcid.org/0000-0002-3615-8075) (Statistician and Co-applicant) provided senior statistical support throughout the trial.
Lindsay Thomson (https://orcid.org/0000-0002-0748-6547) (Principle Investigator and Co-applicant) was instrumental in the development of the trial, led the group in Scotland and contributed to analysis and interpretation of the trial findings.
All authors contributed to the writing of the report and had the opportunity to revise it prior to submission.
Publications
Asherson P, Johansson L, Holland R, Fahy T, Forester A, Howitt S, et al. Randomised controlled trial of the short-term effects of OROS-methylphenidate on ADHD symptoms and behavioural outcomes in young male prisoners with attention-deficit/hyperactivity disorder (CIAO-II). Trials 2019;20:663.
Asherson P, Johansson L, Holland R, Bedding M, Forrester A, Giannulli L, et al. Randomised controlled trial of the short-term effects of osmotic-release oral system methylphenidate on symptoms and behavioural outcomes in young male prisoners with attention deficit hyperactivity disorder: CIAO-II study [published online ahead of print June 3 2022]. Br J Psychiatry 2022.
Data-sharing statement
All data-sharing requests should be submitted to the corresponding author for consideration. Access to available anonymised data may be granted, following review. The data set that will be shared will be a pseudo-anonymised data set and will not include date of birth, initials or prison name.
Patient data
This work uses data provided by patients and collected by the NHS as part of their care and support. Using patient data is vital to improve health and care for everyone. There is huge potential to make better use of information from people’s patient records, to understand more about disease, develop new treatments, monitor safety, and plan NHS services. Patient data should be kept safe and secure, to protect everyone’s privacy, and it’s important that there are safeguards to make sure that it is stored and used responsibly. Everyone should be able to find out about how patient data are used. #datasaveslives You can find out more about the background to this citation here: https://understandingpatientdata.org.uk/data-citation.
Disclaimers
This report presents independent research. The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the NHS, the NIHR, the MRC, the EME programme or the Department of Health and Social Care. If there are verbatim quotations included in this publication the views and opinions expressed by the interviewees are those of the interviewees and do not necessarily reflect those of the authors, those of the NHS, the NIHR, the EME programme or the Department of Health and Social Care.