Objectives | Medical management and intervention (using neurosurgical resection or stereotactic radiosurgery) versus medical management alone for symptomatic brain cavernoma: the CARE pilot RCT

Medical management and intervention (using neurosurgical resection or stereotactic radiosurgery) versus medical management alone for symptomatic brain cavernoma: the CARE pilot RCT · Objectives

Objectives

CC BY 4.0 · National Institute for Health and Care Research · approximately 1 min read

Engage the UK and Ireland patient advocacy organisations for cavernoma and representatives of clinical neurology, neurosurgery and stereotactic radiosurgery at all neuroscience centres throughout the UK and Ireland in a collaboration.
Conduct the following studies:
1. A pilot phase of the CARE parallel-group RCT for patients with symptomatic brain cavernoma, comparing medical management and intervention (using neurosurgical resection or stereotactic radiosurgery) with medical management alone.
2. An integrated QRI incorporating mixed-methods research to triangulate data from screening logs and a range of qualitative sources, to understand recruitment processes and barriers, and identify actions to optimise informed consent and recruitment.
Estimate the feasibility of performing a definitive CARE RCT by extending the UK collaboration to other patient support organisations, clinical communities and funders elsewhere in the world.

Attribution. Rustam Al-Shahi Salman; Neil Kitchen; Laura Forsyth; Vijeya Ganesan; Peter S Hall; Kirsty Harkness et al. (2025). Medical management and intervention (using neurosurgical resection or stereotactic radiosurgery) versus medical management alone for symptomatic brain cavernoma: the CARE pilot RCT. National Institute for Health and Care Research. Copyright © 2025 Al-Shahi Salman et al. Licensed under CC BY 4.0. NCBI Bookshelf NBK617151. CC BY 4.0. Original source ↗. Text reproduced from the Bookshelf XML without changing wording; figures, images and supplements are not reproduced.