List of supplementary material | High-flow nasal cannula therapy versus continuous positive airway pressure for non-invasive respiratory support in paediatric critical care: the FIRST-ABC RCTs

High-flow nasal cannula therapy versus continuous positive airway pressure for non-invasive respiratory support in paediatric critical care: the FIRST-ABC RCTs · List of supplementary material

List of supplementary material

CC BY 4.0 · National Institute for Health and Care Research · approximately 1 min read

Participant information sheet
Consent form
Step-up RCT – subgroup analysis for the cost-effectiveness analysis at 6 months
Step-up RCT – sensitivity analysis for the cost-effectiveness analysis at 6 months
Step-down RCT – screening, randomisation and follow-up in the per-protocol population
Step-down RCT – baseline characteristics in all randomised and consented children irrespective of whether respiratory support was started or not
Step-down RCT – devices and interfaces used in children who started the allocated treatment
Step-down RCT – timing and reasons for treatment failure (switch/escalation events) in children who started the allocated treatment
Step-down RCT – breakdown of the time to liberation from respiratory support by occurrence of treatment failure in children who started the allocated treatment
Step-down RCT – time to reintubation in the modified intention-to-treat population
Step-down RCT – characteristics of children who died within 6 months of randomisation in the primary analysis set
Step-down RCT – sensitivity analyses
Step-down RCT – mean (SD) resource use from Health Services Questionnaire between discharge from hospital and 6 months following initial critical care episode for patients who were alive and completed the questionnaire at 6 months post randomisation
Step-down RCT – subgroup analysis for the cost-effectiveness analysis at 6 months
Step-down RCT – sensitivity analysis for the cost-effectiveness analysis at 6 months

Supplementary material can be found on the NIHR Journals Library report page (https://doi.org/10.3310/PDBG1495).

Supplementary material has been provided by the authors to support the report and any files provided at submission will have been seen by peer reviewers, but not extensively reviewed. Any supplementary material provided at a later stage in the process may not have been peer reviewed.

Attribution. Padmanabhan Ramnarayan; Alvin Richards-Belle; Karen Thomas; Laura Drikite; Zia Sadique; Silvia Moler Zapata et al. (2025). High-flow nasal cannula therapy versus continuous positive airway pressure for non-invasive respiratory support in paediatric critical care: the FIRST-ABC RCTs. National Institute for Health and Care Research. Copyright © 2025 Ramnarayan et al. Licensed under CC BY 4.0. NCBI Bookshelf NBK614104. CC BY 4.0. Original source ↗. Text reproduced from the Bookshelf XML without changing wording; figures, images and supplements are not reproduced.