Definition and research guide
This page combines a MeSH definition, publication statistics and selected research abstracts. It is a starting point for reading the literature, not a medical textbook or a systematic evidence review.
Content available: 4 complete abstracts (665 words), 10 references. Full article text is not stored or reproduced here; follow the PMID, DOI or PMC links to read the original sources and their access terms.
Definition
A space in which the pressure is far below atmospheric pressure so that the remaining gases do not affect processes being carried on in the space.
Definition: NLM Medical Subject Headings (MeSH) scope note (Public domain (U.S. National Library of Medicine); attribution requested). View the MeSH record.
Also known as: Vacuums.
Where it fits in the MeSH classification
- Broader topics
- Pressure; Atmospheric Pressure
Research landscape
PubMed indexes 7,102 records tagged with the MeSH heading “Vacuum” (counts retrieved 2026-10-31). 1,458 of them (20.5%) were published from 2020 onward, and the busiest period so far is 2010-2019 with 2,316 records.
Reviews account for 355 records (5.0%) and meta-analyses for 30. Randomized controlled trials number 173 (2.4%) as a share of all records on the topic.
Show the data
| Period | Records |
|---|---|
| through 1999 | 1,421 |
| 2000-2009 | 1,907 |
| 2010-2019 | 2,316 |
| 2020 onward | 1,458 |
Publication-type chart data
| Type | Records | Share |
|---|---|---|
| Reviews | 355 | 5.0% |
| Meta-analyses | 30 | 0.4% |
| Randomized controlled trials | 173 | 2.4% |
Method: PubMed query "Vacuum"[MeSH Terms] with publication-type and date filters, retrieved 2026-10-31.
Reading the evidence in public health and nutrition
Population and nutrition studies mostly observe what people eat, breathe or are exposed to and then look for links with health, which shows association and not proof of cause. Self-reported diet is imprecise, people who eat or live differently also differ in other ways, and effects measured across a population may not apply to one person. Check the study design, how exposure was measured, what else was accounted for and the size of the effect, not only whether it was statistically significant.
Evidence from open-access studies
These open-access studies come from PubMed’s best-match results for this heading (papers whose main topic it is), ranked here by citation count, with one recent addition. Each abstract is reproduced in full under its recorded open licence so that you can read the authors’ own words. They illustrate the literature; they are not a systematic summary of it. Citation counts measure attention, not reliability or clinical benefit.
Applicability of vacuum impregnation to modify physico-chemical, sensory and nutritive characteristics of plant origin products--a review [1]
Abstract reading summary — source excerpts
- Opening excerpt
- Vacuum impregnation is a non-destructive method of introducing a solution with a specific composition to the porous matrices of fruit and vegetables.
- Closing excerpt
- Additionally, bioactive compounds may be introduced together with impregnating solutions, thus improving health-promoting properties of the product or facilitating production of functional food.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (111 words)
Vacuum impregnation is a non-destructive method of introducing a solution with a specific composition to the porous matrices of fruit and vegetables. Mass transfer in this process is a result of mechanically induced differences in pressure. Vacuum impregnation makes it possible to fill large volumes of intercellular spaces in tissues of fruit and vegetables, thus modifying physico-chemical properties and sensory attributes of products. This method may be used, e.g., to reduce pH and water activity of the product, change its thermal properties, improve texture, color, taste and aroma. Additionally, bioactive compounds may be introduced together with impregnating solutions, thus improving health-promoting properties of the product or facilitating production of functional food.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 25244012 · DOI · PMC4200760
A hybrid microfluidic-vacuum device for direct interfacing with conventional cell culture methods [2]
Abstract reading summary — source excerpts
- Opening excerpt
- BackgroundMicrofluidics is an enabling technology with a number of advantages over traditional tissue culture methods when precise control of cellular microenvironment is required.
- Closing excerpt
- This platform provides a simple yet versatile tool for incorporating the advantages of a microfluidic approach to biological assays without changing established tissue culture protocols.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (211 words)
BackgroundMicrofluidics is an enabling technology with a number of advantages over traditional tissue culture methods when precise control of cellular microenvironment is required. However, there are a number of practical and technical limitations that impede wider implementation in routine biomedical research. Specialized equipment and protocols required for fabrication and setting up microfluidic experiments present hurdles for routine use by most biology laboratories.ResultsWe have developed and validated a novel microfluidic device that can directly interface with conventional tissue culture methods to generate and maintain controlled soluble environments in a Petri dish. It incorporates separate sets of fluidic channels and vacuum networks on a single device that allows reversible application of microfluidic gradients onto wet cell culture surfaces. Stable, precise concentration gradients of soluble factors were generated using simple microfluidic channels that were attached to a perfusion system. We successfully demonstrated real-time optical live/dead cell imaging of neural stem cells exposed to a hydrogen peroxide gradient and chemotaxis of metastatic breast cancer cells in a growth factor gradient.ConclusionThis paper describes the design and application of a versatile microfluidic device that can directly interface with conventional cell culture methods. This platform provides a simple yet versatile tool for incorporating the advantages of a microfluidic approach to biological assays without changing established tissue culture protocols.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 17883868 · DOI · PMC2071914
Overall Quality of Fruits and Vegetables Products Affected by the Drying Processes with the Assistance of Vacuum-Microwaves [3]
Abstract reading summary — source excerpts
- Opening excerpt
- The seasonality of fruits and vegetables makes it impossible to consume and use them throughout the year, thus numerous processing efforts have been made to offer an alternative to their fresh consumption and application.
- Closing excerpt
- In conclusion, the most promising way for improving the quality of dried fruit and vegetable products is hybrid drying consisting of osmotic dehydration in concentrated fruit juices followed by heat pump drying and vacuum-microwave finish drying.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (208 words)
The seasonality of fruits and vegetables makes it impossible to consume and use them throughout the year, thus numerous processing efforts have been made to offer an alternative to their fresh consumption and application. To prolong their availability on the market, drying has received special attention as currently this method is considered one of the most common ways for obtaining food and pharmaceutical products from natural sources. This paper demonstrates the weakness of common drying methods applied for fruits and vegetables and the possible ways to improve the quality using different drying techniques or their combination with an emphasis on the microwave energy. Particular attention has been drawn to the combined drying with the assistance of vacuum-microwaves. The quality of the dried products was ascribed by chemical properties including the content of polyphenols, antioxidant capacity and volatiles as well as physical parameters such as color, shrinkage, porosity and texture. Both these fields of quality classification were considered taking into account sensory attributes and energy aspects in the perspective of possible industrial applications. In conclusion, the most promising way for improving the quality of dried fruit and vegetable products is hybrid drying consisting of osmotic dehydration in concentrated fruit juices followed by heat pump drying and vacuum-microwave finish drying.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 28042845 · DOI · PMC5297706
Patients with an Open Abdomen in Asian, American and European Continents: A Comparative Analysis from the International Register of Open Abdomen (IROA) [4]
Abstract reading summary — source excerpts
- Opening excerpt
- BackgroundInternational register of open abdomen (IROA) enrolls patients from several centers in American, European, and Asiatic continent.
- Closing excerpt
- Adherence to guidelines, combined with more consistent data, will ultimately allow to improving knowledge and outcome.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (135 words)
BackgroundInternational register of open abdomen (IROA) enrolls patients from several centers in American, European, and Asiatic continent. The aim of our study is to compare the characteristics, management and clinical outcome of adult patients treated with OA in the three continents.Material and methodsA prospective analysis of adult patients enrolled in the international register of open abdomen (IROA).Trial registrationNCT02382770.Results1183 patients were enrolled from American, European and Asiatic Continent. Median age was 63 years (IQR 49-74) and was higher in the European continent (65 years, p ConclusionThere is no uniformity in OA management in the different continents. Heterogeneous adherence to international guidelines application is evident. Different temporary abdominal closure techniques in relation to indications led to different outcomes across the continents. Adherence to guidelines, combined with more consistent data, will ultimately allow to improving knowledge and outcome.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 36326921 · DOI · PMC9726668
Key reviews and meta-analyses
The most cited review-type papers among PubMed’s best-match results for this heading, listed with bibliographic details only. Follow the links for the full text and access terms.
- Research article Implants, mechanical devices, and vascular surgery for erectile dysfunction [5]
- Research article Topical negative pressure for treating chronic wounds: a systematic review [6]
- Research article The efficacy of negative pressure wound therapy in the management of lower extremity trauma: review of clinical evidence [7]
- Research article Bicomponent Supramolecular Architectures at the Vacuum-Solid Interface [8]
- Research article Recent advances and applications of gas chromatography vacuum ultraviolet spectroscopy [9]
- Research article The role of percutaneous vacuum-assisted thrombectomy for intracardiac and intravascular pathology [10]
References
- Radziejewska-Kubzdela E, Biegańska-Marecik R, Kidoń M. Applicability of vacuum impregnation to modify physico-chemical, sensory and nutritive characteristics of plant origin products--a review. . 2014. PMID 25244012 · DOI · PMC4200760
- Chung BG, Park JW, Hu JS, Huang C, Monuki ES, Jeon NL. A hybrid microfluidic-vacuum device for direct interfacing with conventional cell culture methods. . 2007. PMID 17883868 · DOI · PMC2071914
- Figiel A, Michalska A. Overall Quality of Fruits and Vegetables Products Affected by the Drying Processes with the Assistance of Vacuum-Microwaves. . 2016. PMID 28042845 · DOI · PMC5297706
- Sibilla MG, Cremonini C, Portinari M, Carcoforo P, Tartaglia D, Cicuttin E, et al.. Patients with an Open Abdomen in Asian, American and European Continents: A Comparative Analysis from the International Register of Open Abdomen (IROA). . 2023. PMID 36326921 · DOI · PMC9726668
- Hellstrom WJ, Montague DK, Moncada I, Carson C, Minhas S, Faria G, et al.. Implants, mechanical devices, and vascular surgery for erectile dysfunction. J Sex Med. 2010. PMID 20092450 · DOI
- Evans D, Land L. Topical negative pressure for treating chronic wounds: a systematic review. Br J Plast Surg. 2001. PMID 11254418 · DOI
- Kanakaris NK, Thanasas C, Keramaris N, Kontakis G, Granick MS, Giannoudis PV. The efficacy of negative pressure wound therapy in the management of lower extremity trauma: review of clinical evidence. Injury. 2007. PMID 18045598 · DOI
- Bouju X, Mattioli C, Franc G, Pujol A, Gourdon A. Bicomponent Supramolecular Architectures at the Vacuum-Solid Interface. Chem Rev. 2017. PMID 28097870 · DOI
- Santos IC, Schug KA. Recent advances and applications of gas chromatography vacuum ultraviolet spectroscopy. J Sep Sci. 2017. PMID 27902885 · DOI
- Basman C, Rashid U, Parmar YJ, Kliger C, Kronzon I. The role of percutaneous vacuum-assisted thrombectomy for intracardiac and intravascular pathology. J Card Surg. 2018. PMID 30187515 · DOI
About this article
- Sources
- NLM Medical Subject Headings (definition, synonyms); NCBI PubMed (counts, identifiers); Europe PMC (open-access abstracts and citation counts).
- Verification
- Every reference was resolved against PubMed on 2026-11-04; title, year and DOI matched.
- Review state
- automated source verified; no human expert review has been recorded yet.
- Version
- 1, last updated 2026-11-04.
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Evidence strength
EvidenceHelix's computed view of the study designs behind this topic: how common meta-analyses, randomized trials and reviews are, how recent the literature is, and a plain-language reading. It describes the design mix of the literature. It is not a quality appraisal of any study, and it is not medical advice.