Definition and research guide
This page combines a MeSH definition, publication statistics and selected research abstracts. It is a starting point for reading the literature, not a medical textbook or a systematic evidence review.
Content available: 4 complete abstracts (932 words), 10 references. Full article text is not stored or reproduced here; follow the PMID, DOI or PMC links to read the original sources and their access terms.
Definition
The first digit on the radial side of the hand which in humans lies opposite the other four.
Definition: NLM Medical Subject Headings (MeSH) scope note (Public domain (U.S. National Library of Medicine); attribution requested). View the MeSH record.
Also known as: Thumbs.
Where it fits in the MeSH classification
- Broader topics
- Fingers
Research landscape
PubMed indexes 10,623 records tagged with the MeSH heading “Thumb” (counts retrieved 2026-10-31). 1,609 of them (15.1%) were published from 2020 onward, and the busiest period so far is through 1999 with 5,036 records.
Reviews account for 870 records (8.2%) and meta-analyses for 40. Randomized controlled trials number 203 (1.9%) as a share of all records on the topic. Randomized trials make up only a small share of this literature, so much of what is known comes from laboratory, observational or descriptive work.
Show the data
| Period | Records |
|---|---|
| through 1999 | 5,036 |
| 2000-2009 | 1,812 |
| 2010-2019 | 2,166 |
| 2020 onward | 1,609 |
Publication-type chart data
| Type | Records | Share |
|---|---|---|
| Reviews | 870 | 8.2% |
| Meta-analyses | 40 | 0.4% |
| Randomized controlled trials | 203 | 1.9% |
Method: PubMed query "Thumb"[MeSH Terms] with publication-type and date filters, retrieved 2026-10-31.
Reading the evidence in anatomy and physiology
Anatomy describes how body structures are built and physiology describes how they normally work, so most findings here are descriptive or mechanistic rather than evidence about treatment. Much of what is known comes from dissection, imaging, tissue studies and experiments in animals, and measurements in healthy volunteers can differ from those in people with disease or at different ages. Normal ranges vary between individuals and populations. Check whether a result was measured in people or in another species, the age and health of the participants, and the method used.
Evidence from open-access studies
These open-access studies come from PubMed’s best-match results for this heading (papers whose main topic it is), ranked here by citation count, with one recent addition. Each abstract is reproduced in full under its recorded open licence so that you can read the authors’ own words. They illustrate the literature; they are not a systematic summary of it. Citation counts measure attention, not reliability or clinical benefit.
| Study / authors | Year | Source label / design | Europe PMC citations | Licence / source |
|---|---|---|---|---|
| The association between smartphone addiction and thumb/wrist pain: A cross-sectional study | 2020 | Research article Design not recorded in structured metadata | 44 | cc by PMID 32150053 · DOI · PMC7478614 |
| Biomechanics of the human thumb and the evolution of dexterity | 2021 | Research article Design not recorded in structured metadata | 38 | cc by PMID 33513351 · DOI · PMC7987722 |
| Leukocyte-Reduced Platelet-Rich Plasma Treatment of Basal Thumb Arthritis: A Pilot Study | 2016 | Clinical trial Design not recorded in structured metadata | 28 | cc by PMID 27478842 · DOI · PMC4949344 |
| Occupational risk factors for thumb carpometacarpal joint osteoarthritis: a register-based study of construction workers | 2025 | Research article Design not recorded in structured metadata | 4 | cc by PMID 39904624 · DOI · PMC12015016 |
The association between smartphone addiction and thumb/wrist pain: A cross-sectional study [1]
Abstract reading summary — source excerpts
- Opening excerpt
- Many smartphone users experience pain in the thumb/wrist.
- Closing excerpt
- Our study found the prevalence of smartphones addiction among university students to be high (66%), furthermore a correlation between heavy smartphones usage and hand pain was found which indicates that heavy usage of these devices can cause subclinical effects on the human hand.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (211 words)
Many smartphone users experience pain in the thumb/wrist. This pain can be due to certain types of hand injuries as well as inflammation of the extensor pollicis brevis and the abductor pollicis longus tendon sheaths, known as De Quervain tenosynovitis. The objective of this study was to evaluate the association between smartphone addiction and wrist/thumb pain and to determine the severity of the pain, as well as to calculate the prevalence of De Quervain tenosynovitis among medical students at King Abdulaziz University (KAU) in Jeddah.A total of 387 medical students were enrolled. The smartphone addiction scale-short version (SAS-SV) was used to divide participants into the smartphone addict group and non-addict group. Both groups completed the self-administered patient-rated wrist and hand evaluation (PRWHE) questionnaire to evaluate wrist/hand pain. The Finkelstein test was administered to those who reported pain in the thumb/wrist.Two hundred fifty-seven (66.4%) participants were smartphone addicts; 74 (19.1%) had a positive Finkelstein test. There was a significant correlation between smartphone addiction and high PRWHE scores (P = .036).Our study found the prevalence of smartphones addiction among university students to be high (66%), furthermore a correlation between heavy smartphones usage and hand pain was found which indicates that heavy usage of these devices can cause subclinical effects on the human hand.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 32150053 · DOI · PMC7478614
Biomechanics of the human thumb and the evolution of dexterity [2]
Abstract reading summary — source excerpts
- Opening excerpt
- Systematic tool production and use is one of humanity's defining characteristics, possibly originating as early as >3 million years ago.
- Closing excerpt
- In contrast, later Homo species, including the small-brained Homo naledi, show high levels of thumb opposition dexterity, highlighting the increasing importance of cultural processes and manual dexterity in later human evolution.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (226 words)
Systematic tool production and use is one of humanity's defining characteristics, possibly originating as early as >3 million years ago.1-3 Although heightened manual dexterity is considered to be intrinsically intertwined with tool use and manufacture, and critical for human evolution, its role in the emergence of early culture remains unclear. Most previous research on this question exclusively relied on direct morphological comparisons between early hominin and modern human skeletal elements, assuming that the degree of a species' dexterity depends on its similarity with the modern human form. Here, we develop a new approach to investigate the efficiency of thumb opposition, a fundamental component of manual dexterity, in several species of fossil hominins. Our work for the first time takes into account soft tissue as well as bone anatomy, integrating virtual modeling of musculus opponens pollicis and its interaction with three-dimensional bone shape form. Results indicate that a fundamental aspect of efficient thumb opposition appeared approximately 2 million years ago, possibly associated with our own genus Homo, and did not characterize Australopithecus, the earliest proposed stone tool maker. This was true also of the late Australopithecus species, Australopithecus sediba, previously found to exhibit human-like thumb proportions. In contrast, later Homo species, including the small-brained Homo naledi, show high levels of thumb opposition dexterity, highlighting the increasing importance of cultural processes and manual dexterity in later human evolution.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 33513351 · DOI · PMC7987722
Leukocyte-Reduced Platelet-Rich Plasma Treatment of Basal Thumb Arthritis: A Pilot Study [3]
Abstract reading summary — source excerpts
- Opening excerpt
- A positive effect of intra-articular platelet-rich plasma (PRP) injection has been discussed for osteoarthritic joint conditions in the last years.
- Closing excerpt
- PRP injection for symptomatic TMC OA is a reasonable therapeutic option in early stages TMC OA and can be performed with little to no morbidity.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (232 words)
A positive effect of intra-articular platelet-rich plasma (PRP) injection has been discussed for osteoarthritic joint conditions in the last years. The purpose of this study was to evaluate PRP injection into the trapeziometacarpal (TMC) joint. We report about ten patients with TMC joint osteoarthritis (OA) that were treated with 2 intra-articular PRP injections 4 weeks apart. PRP was produced using the Double Syringe System (Arthrex Inc., Naples, Florida, USA). A total volume of 1.47 ± 0.25 mL PRP was injected at the first injection and 1.5 ± 0.41 mL at the second injection, depending on the volume capacity of the joint. Patients were evaluated using VAS, strength measures, and the Mayo Wrist score and DASH score after 3 and 6 months. VAS significantly decreased from 6.2 ± 1.6 to 5.4 ± 2.2 at six-month follow-up (P < 0.05). The DASH score was unaffected; however, the Mayo Wrist score significantly improved from 46.5 ± 18.6 to 67.5 ± 19.0 at six-month follow-up (P = 0.05). Grip was unaffected, whereas pinch declined from 6.02 ± 2.99 to 3.96 ± 1.77 at six-month follow-up (P < 0.05). We did not observe adverse events after the injection of PRP, except one occurrence of a palmar wrist ganglion, which resolved without treatment. PRP injection for symptomatic TMC OA is a reasonable therapeutic option in early stages TMC OA and can be performed with little to no morbidity.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 27478842 · DOI · PMC4949344
Occupational risk factors for thumb carpometacarpal joint osteoarthritis: a register-based study of construction workers [4]
Abstract reading summary — source excerpts
- Opening excerpt
- ObjectivesThe study investigated the association between occupational biomechanical risk factors and the occurrence of thumb carpometacarpal joint osteoarthritis (CMC1 OA) in construction workers.
- Closing excerpt
- ConclusionWrist movements and hand loading were associated with CMC1 OA.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (263 words)
ObjectivesThe study investigated the association between occupational biomechanical risk factors and the occurrence of thumb carpometacarpal joint osteoarthritis (CMC1 OA) in construction workers.MethodsMale construction workers (n=237 525), participating in a Swedish occupational surveillance programme between 1971 and 1993, were followed between 1997 and 2019. CMC1 OA diagnoses were identified through linkage with national medical registries. Job title, smoking status, height, weight and age were collected from the surveillance programme. A job exposure matrix (JEM) was developed with exposure estimates on biomechanical risk factors for each occupational group. Relative risk (RR) of CMC1 OA diagnosis was calculated using a Poisson regression model.ResultsThere was an increased risk of CMC1 OA for all biomechanical risk factors (RR range 1.3-1.5). Exposure-response patterns were seen for repetitive wrist flexion and extension (low: RR 1.30 (95% CI 1.07 to 1.59), moderate: 1.32 (95% CI 1.07 to 1.62), high: 1.45 (95% CI 1.19 to 1.75)), wrist extension (low: 1.31 (95% CI 1.09 to 1.59), moderate: 1.41 (95% CI 1.17 to 1.70) and heavy lifting (low: 1.13 (95% CI 0.92 to 1.38), moderate: 1.45 (95% CI 1.18 to 1.77), high: 1.50 (95% CI 1.24 to 1.82). Electricians (1.29 (95% CI 1.03 to 1.89)), concrete workers (1.31 (95% CI 1.02 to 1.67)), plumbers (1.37 (95% CI 1.07 to 1.76)), sheet-metal workers (1.58 (95% CI 1.18 to 2.10)), wood workers (1.66 (95% CI 1.36 to 2.03)), repairers (1.75 (95% CI 1.06 to 2.90)) and glass workers (2.21 (95% CI 1.42 to 3.44) had an increased risk of CMC1 OA compared with the reference group.ConclusionWrist movements and hand loading were associated with CMC1 OA.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 39904624 · DOI · PMC12015016
Key reviews and meta-analyses
The most cited review-type papers among PubMed’s best-match results for this heading, listed with bibliographic details only. Follow the links for the full text and access terms.
- Research article Thumb carpometacarpal joint total arthroplasty: a systematic review [5]
- Research article Conservative treatment of thumb base osteoarthritis: a systematic review [6]
- Research article Thumb carpal metacarpal arthritis [7]
- Research article Current concepts of the anatomy of the thumb trapeziometacarpal joint [8]
- Research article Repair and reconstruction of thumb and finger tip injuries: a global view [9]
- Research article De Quervain's tenosynovitis. Stenosing tenosynovitis of the first dorsal compartment [10]
References
- Baabdullah A, Bokhary D, Kabli Y, Saggaf O, Daiwali M, Hamdi A. The association between smartphone addiction and thumb/wrist pain: A cross-sectional study. . 2020. PMID 32150053 · DOI · PMC7478614
- Karakostis FA, Haeufle D, Anastopoulou I, Moraitis K, Hotz G, Tourloukis V, et al.. Biomechanics of the human thumb and the evolution of dexterity. . 2021. PMID 33513351 · DOI · PMC7987722
- Loibl M, Lang S, Dendl LM, Nerlich M, Angele P, Gehmert S, et al.. Leukocyte-Reduced Platelet-Rich Plasma Treatment of Basal Thumb Arthritis: A Pilot Study. . 2016. PMID 27478842 · DOI · PMC4949344
- Lewis C, Jackson JA, Stjernbrandt A, Andersson G, Mukka S, Wahlström J, et al.. Occupational risk factors for thumb carpometacarpal joint osteoarthritis: a register-based study of construction workers. . 2025. PMID 39904624 · DOI · PMC12015016
- Huang K, Hollevoet N, Giddins G. Thumb carpometacarpal joint total arthroplasty: a systematic review. J Hand Surg Eur Vol. 2015. PMID 25600851 · DOI
- Spaans AJ, van Minnen LP, Kon M, Schuurman AH, Schreuders AR, Vermeulen GM. Conservative treatment of thumb base osteoarthritis: a systematic review. J Hand Surg Am. 2015. PMID 25534834 · DOI
- Van Heest AE, Kallemeier P. Thumb carpal metacarpal arthritis. J Am Acad Orthop Surg. 2008. PMID 18316712 · DOI
- Edmunds JO. Current concepts of the anatomy of the thumb trapeziometacarpal joint. J Hand Surg Am. 2011. PMID 21193137 · DOI
- Tang JB, Elliot D, Adani R, Saint-Cyr M, Stang F. Repair and reconstruction of thumb and finger tip injuries: a global view. Clin Plast Surg. 2014. PMID 24996458 · DOI
- Moore JS. De Quervain's tenosynovitis. Stenosing tenosynovitis of the first dorsal compartment. J Occup Environ Med. 1997. PMID 9343764 · DOI
About this article
- Sources
- NLM Medical Subject Headings (definition, synonyms); NCBI PubMed (counts, identifiers); Europe PMC (open-access abstracts and citation counts).
- Verification
- Every reference was resolved against PubMed on 2026-10-31; title, year and DOI matched.
- Review state
- automated source verified; no human expert review has been recorded yet.
- Version
- 1, last updated 2026-10-31.
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Evidence strength
EvidenceHelix's computed view of the study designs behind this topic: how common meta-analyses, randomized trials and reviews are, how recent the literature is, and a plain-language reading. It describes the design mix of the literature. It is not a quality appraisal of any study, and it is not medical advice.