Skip to content
EvidenceHelixEvidenceLib · Scientific Encyclopedia
⌘ K

Scientific library

EvidenceLib encyclopediaAll articles A–Z2,100Open textbooks2Cancer study catalog458How it is made

My workspace this browser

Saved pages0Notes & annotations0

Recently viewed

Explore by field

Cancer and Oncology107Genetics and Genomics95Neuroscience110Cardiovascular Medicine105Immunology90Pharmacology99Molecular Biology100Infectious Diseases102Rare and Inherited Diseases106Clinical Research98Anatomy and Physiology542Drugs and Chemicals546
Plans & pricingCompare EvidenceHelix workspace plans
Library›EvidenceLib›Anatomy and Physiology›Thumb
Explore more with EvidenceHelix Workspace

Compare studies, analyze evidence and create research reports with premium tools.

Explore Researcher plans

Research reading room

Thumb

Anatomy and Physiology · NLM MeSH · updated 2026-10-31 · version 1

Citations verified against PubMedNot yet clinician-reviewed10 referencesApproximately 5 min read

The first digit on the radial side of the hand which in humans lies opposite the other four.

Table of Contents

1. Definition2. Research landscape3. Reading the evidence4. Open-access studies5. Key reviews6. References7. About this article

Definition and research guide

This page combines a MeSH definition, publication statistics and selected research abstracts. It is a starting point for reading the literature, not a medical textbook or a systematic evidence review.

Content available: 4 complete abstracts (932 words), 10 references. Full article text is not stored or reproduced here; follow the PMID, DOI or PMC links to read the original sources and their access terms.

Definition

The first digit on the radial side of the hand which in humans lies opposite the other four.

Definition: NLM Medical Subject Headings (MeSH) scope note (Public domain (U.S. National Library of Medicine); attribution requested). View the MeSH record.

Also known as: Thumbs.

Where it fits in the MeSH classification

Broader topics
Fingers

Research landscape

PubMed indexes 10,623 records tagged with the MeSH heading “Thumb” (counts retrieved 2026-10-31). 1,609 of them (15.1%) were published from 2020 onward, and the busiest period so far is through 1999 with 5,036 records.

Reviews account for 870 records (8.2%) and meta-analyses for 40. Randomized controlled trials number 203 (1.9%) as a share of all records on the topic. Randomized trials make up only a small share of this literature, so much of what is known comes from laboratory, observational or descriptive work.

PubMed records by publication periodthrough 1999: 5,036 records; 2000-2009: 1,812 records; 2010-2019: 2,166 records; 2020 onward: 1,609 records5,036through 19991,8122000-20092,1662010-20191,6092020 onward
Records in PubMed indexed with this heading, by publication period. Real counts from NCBI E-utilities; the final period covers only part of the current year. Volume reflects how much has been published, not how strong the evidence is.
Show the data
PeriodRecords
through 19995,036
2000-20091,812
2010-20192,166
2020 onward1,609
Share of records by publication typeReviews: 8.2 percent; Meta-analyses: 0.4 percent; Randomized controlled trials: 1.9 percentReviews8.2% (870)Meta-analyses0.4% (40)Randomized controlled trials1.9% (203)
Share of all PubMed records on this heading that carry each publication type. Types overlap with other records, so the shares do not sum to 100%.
Publication-type chart data
Publication types among 10,623 PubMed records
TypeRecordsShare
Reviews8708.2%
Meta-analyses400.4%
Randomized controlled trials2031.9%

Method: PubMed query "Thumb"[MeSH Terms] with publication-type and date filters, retrieved 2026-10-31.

Reading the evidence in anatomy and physiology

Anatomy describes how body structures are built and physiology describes how they normally work, so most findings here are descriptive or mechanistic rather than evidence about treatment. Much of what is known comes from dissection, imaging, tissue studies and experiments in animals, and measurements in healthy volunteers can differ from those in people with disease or at different ages. Normal ranges vary between individuals and populations. Check whether a result was measured in people or in another species, the age and health of the participants, and the method used.

Evidence from open-access studies

These open-access studies come from PubMed’s best-match results for this heading (papers whose main topic it is), ranked here by citation count, with one recent addition. Each abstract is reproduced in full under its recorded open licence so that you can read the authors’ own words. They illustrate the literature; they are not a systematic summary of it. Citation counts measure attention, not reliability or clinical benefit.

Study comparison — selected abstracts, not a systematic review
Study / authorsYearSource label / designEurope PMC citationsLicence / source
The association between smartphone addiction and thumb/wrist pain: A cross-sectional study
Baabdullah A, Bokhary D, Kabli Y, Saggaf O, Daiwali M, Hamdi A
2020Research article
Design not recorded in structured metadata
44cc by
PMID 32150053 · DOI · PMC7478614
Biomechanics of the human thumb and the evolution of dexterity
Karakostis FA, Haeufle D, Anastopoulou I, Moraitis K, Hotz G, Tourloukis V, et al.
2021Research article
Design not recorded in structured metadata
38cc by
PMID 33513351 · DOI · PMC7987722
Leukocyte-Reduced Platelet-Rich Plasma Treatment of Basal Thumb Arthritis: A Pilot Study
Loibl M, Lang S, Dendl LM, Nerlich M, Angele P, Gehmert S, et al.
2016Clinical trial
Design not recorded in structured metadata
28cc by
PMID 27478842 · DOI · PMC4949344
Occupational risk factors for thumb carpometacarpal joint osteoarthritis: a register-based study of construction workers
Lewis C, Jackson JA, Stjernbrandt A, Andersson G, Mukka S, Wahlström J, et al.
2025Research article
Design not recorded in structured metadata
4cc by
PMID 39904624 · DOI · PMC12015016

The association between smartphone addiction and thumb/wrist pain: A cross-sectional study [1]

Research article Baabdullah A, Bokhary D, Kabli Y, Saggaf O, Daiwali M, Hamdi A · · 2020 · cited 44 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
Many smartphone users experience pain in the thumb/wrist.
Closing excerpt
Our study found the prevalence of smartphones addiction among university students to be high (66%), furthermore a correlation between heavy smartphones usage and hand pain was found which indicates that heavy usage of these devices can cause subclinical effects on the human hand.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (211 words)

Many smartphone users experience pain in the thumb/wrist. This pain can be due to certain types of hand injuries as well as inflammation of the extensor pollicis brevis and the abductor pollicis longus tendon sheaths, known as De Quervain tenosynovitis. The objective of this study was to evaluate the association between smartphone addiction and wrist/thumb pain and to determine the severity of the pain, as well as to calculate the prevalence of De Quervain tenosynovitis among medical students at King Abdulaziz University (KAU) in Jeddah.A total of 387 medical students were enrolled. The smartphone addiction scale-short version (SAS-SV) was used to divide participants into the smartphone addict group and non-addict group. Both groups completed the self-administered patient-rated wrist and hand evaluation (PRWHE) questionnaire to evaluate wrist/hand pain. The Finkelstein test was administered to those who reported pain in the thumb/wrist.Two hundred fifty-seven (66.4%) participants were smartphone addicts; 74 (19.1%) had a positive Finkelstein test. There was a significant correlation between smartphone addiction and high PRWHE scores (P = .036).Our study found the prevalence of smartphones addiction among university students to be high (66%), furthermore a correlation between heavy smartphones usage and hand pain was found which indicates that heavy usage of these devices can cause subclinical effects on the human hand.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 32150053 · DOI · PMC7478614

Biomechanics of the human thumb and the evolution of dexterity [2]

Research article Karakostis FA, Haeufle D, Anastopoulou I, Moraitis K, Hotz G, Tourloukis V, et al. · · 2021 · cited 38 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
Systematic tool production and use is one of humanity's defining characteristics, possibly originating as early as >3 million years ago.
Closing excerpt
In contrast, later Homo species, including the small-brained Homo naledi, show high levels of thumb opposition dexterity, highlighting the increasing importance of cultural processes and manual dexterity in later human evolution.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (226 words)

Systematic tool production and use is one of humanity's defining characteristics, possibly originating as early as >3 million years ago.1-3 Although heightened manual dexterity is considered to be intrinsically intertwined with tool use and manufacture, and critical for human evolution, its role in the emergence of early culture remains unclear. Most previous research on this question exclusively relied on direct morphological comparisons between early hominin and modern human skeletal elements, assuming that the degree of a species' dexterity depends on its similarity with the modern human form. Here, we develop a new approach to investigate the efficiency of thumb opposition, a fundamental component of manual dexterity, in several species of fossil hominins. Our work for the first time takes into account soft tissue as well as bone anatomy, integrating virtual modeling of musculus opponens pollicis and its interaction with three-dimensional bone shape form. Results indicate that a fundamental aspect of efficient thumb opposition appeared approximately 2 million years ago, possibly associated with our own genus Homo, and did not characterize Australopithecus, the earliest proposed stone tool maker. This was true also of the late Australopithecus species, Australopithecus sediba, previously found to exhibit human-like thumb proportions. In contrast, later Homo species, including the small-brained Homo naledi, show high levels of thumb opposition dexterity, highlighting the increasing importance of cultural processes and manual dexterity in later human evolution.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 33513351 · DOI · PMC7987722

Leukocyte-Reduced Platelet-Rich Plasma Treatment of Basal Thumb Arthritis: A Pilot Study [3]

Clinical trial Loibl M, Lang S, Dendl LM, Nerlich M, Angele P, Gehmert S, et al. · · 2016 · cited 28 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
A positive effect of intra-articular platelet-rich plasma (PRP) injection has been discussed for osteoarthritic joint conditions in the last years.
Closing excerpt
PRP injection for symptomatic TMC OA is a reasonable therapeutic option in early stages TMC OA and can be performed with little to no morbidity.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (232 words)

A positive effect of intra-articular platelet-rich plasma (PRP) injection has been discussed for osteoarthritic joint conditions in the last years. The purpose of this study was to evaluate PRP injection into the trapeziometacarpal (TMC) joint. We report about ten patients with TMC joint osteoarthritis (OA) that were treated with 2 intra-articular PRP injections 4 weeks apart. PRP was produced using the Double Syringe System (Arthrex Inc., Naples, Florida, USA). A total volume of 1.47 ± 0.25 mL PRP was injected at the first injection and 1.5 ± 0.41 mL at the second injection, depending on the volume capacity of the joint. Patients were evaluated using VAS, strength measures, and the Mayo Wrist score and DASH score after 3 and 6 months. VAS significantly decreased from 6.2 ± 1.6 to 5.4 ± 2.2 at six-month follow-up (P < 0.05). The DASH score was unaffected; however, the Mayo Wrist score significantly improved from 46.5 ± 18.6 to 67.5 ± 19.0 at six-month follow-up (P = 0.05). Grip was unaffected, whereas pinch declined from 6.02 ± 2.99 to 3.96 ± 1.77 at six-month follow-up (P < 0.05). We did not observe adverse events after the injection of PRP, except one occurrence of a palmar wrist ganglion, which resolved without treatment. PRP injection for symptomatic TMC OA is a reasonable therapeutic option in early stages TMC OA and can be performed with little to no morbidity.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 27478842 · DOI · PMC4949344

Occupational risk factors for thumb carpometacarpal joint osteoarthritis: a register-based study of construction workers [4]

Research article Lewis C, Jackson JA, Stjernbrandt A, Andersson G, Mukka S, Wahlström J, et al. · · 2025 · cited 4 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
ObjectivesThe study investigated the association between occupational biomechanical risk factors and the occurrence of thumb carpometacarpal joint osteoarthritis (CMC1 OA) in construction workers.
Closing excerpt
ConclusionWrist movements and hand loading were associated with CMC1 OA.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (263 words)

ObjectivesThe study investigated the association between occupational biomechanical risk factors and the occurrence of thumb carpometacarpal joint osteoarthritis (CMC1 OA) in construction workers.MethodsMale construction workers (n=237 525), participating in a Swedish occupational surveillance programme between 1971 and 1993, were followed between 1997 and 2019. CMC1 OA diagnoses were identified through linkage with national medical registries. Job title, smoking status, height, weight and age were collected from the surveillance programme. A job exposure matrix (JEM) was developed with exposure estimates on biomechanical risk factors for each occupational group. Relative risk (RR) of CMC1 OA diagnosis was calculated using a Poisson regression model.ResultsThere was an increased risk of CMC1 OA for all biomechanical risk factors (RR range 1.3-1.5). Exposure-response patterns were seen for repetitive wrist flexion and extension (low: RR 1.30 (95% CI 1.07 to 1.59), moderate: 1.32 (95% CI 1.07 to 1.62), high: 1.45 (95% CI 1.19 to 1.75)), wrist extension (low: 1.31 (95% CI 1.09 to 1.59), moderate: 1.41 (95% CI 1.17 to 1.70) and heavy lifting (low: 1.13 (95% CI 0.92 to 1.38), moderate: 1.45 (95% CI 1.18 to 1.77), high: 1.50 (95% CI 1.24 to 1.82). Electricians (1.29 (95% CI 1.03 to 1.89)), concrete workers (1.31 (95% CI 1.02 to 1.67)), plumbers (1.37 (95% CI 1.07 to 1.76)), sheet-metal workers (1.58 (95% CI 1.18 to 2.10)), wood workers (1.66 (95% CI 1.36 to 2.03)), repairers (1.75 (95% CI 1.06 to 2.90)) and glass workers (2.21 (95% CI 1.42 to 3.44) had an increased risk of CMC1 OA compared with the reference group.ConclusionWrist movements and hand loading were associated with CMC1 OA.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 39904624 · DOI · PMC12015016

Key reviews and meta-analyses

The most cited review-type papers among PubMed’s best-match results for this heading, listed with bibliographic details only. Follow the links for the full text and access terms.

  • Research article Thumb carpometacarpal joint total arthroplasty: a systematic review [5]
    Huang K, Hollevoet N, Giddins G · J Hand Surg Eur Vol · 2015 · cited 120 times (Europe PMC)
  • Research article Conservative treatment of thumb base osteoarthritis: a systematic review [6]
    Spaans AJ, van Minnen LP, Kon M, Schuurman AH, Schreuders AR, Vermeulen GM · J Hand Surg Am · 2015 · cited 116 times (Europe PMC)
  • Research article Thumb carpal metacarpal arthritis [7]
    Van Heest AE, Kallemeier P · J Am Acad Orthop Surg · 2008 · cited 113 times (Europe PMC)
  • Research article Current concepts of the anatomy of the thumb trapeziometacarpal joint [8]
    Edmunds JO · J Hand Surg Am · 2011 · cited 108 times (Europe PMC)
  • Research article Repair and reconstruction of thumb and finger tip injuries: a global view [9]
    Tang JB, Elliot D, Adani R, Saint-Cyr M, Stang F · Clin Plast Surg · 2014 · cited 94 times (Europe PMC)
  • Research article De Quervain's tenosynovitis. Stenosing tenosynovitis of the first dorsal compartment [10]
    Moore JS · J Occup Environ Med · 1997 · cited 71 times (Europe PMC)

References

  1. Baabdullah A, Bokhary D, Kabli Y, Saggaf O, Daiwali M, Hamdi A. The association between smartphone addiction and thumb/wrist pain: A cross-sectional study. . 2020. PMID 32150053 · DOI · PMC7478614
  2. Karakostis FA, Haeufle D, Anastopoulou I, Moraitis K, Hotz G, Tourloukis V, et al.. Biomechanics of the human thumb and the evolution of dexterity. . 2021. PMID 33513351 · DOI · PMC7987722
  3. Loibl M, Lang S, Dendl LM, Nerlich M, Angele P, Gehmert S, et al.. Leukocyte-Reduced Platelet-Rich Plasma Treatment of Basal Thumb Arthritis: A Pilot Study. . 2016. PMID 27478842 · DOI · PMC4949344
  4. Lewis C, Jackson JA, Stjernbrandt A, Andersson G, Mukka S, Wahlström J, et al.. Occupational risk factors for thumb carpometacarpal joint osteoarthritis: a register-based study of construction workers. . 2025. PMID 39904624 · DOI · PMC12015016
  5. Huang K, Hollevoet N, Giddins G. Thumb carpometacarpal joint total arthroplasty: a systematic review. J Hand Surg Eur Vol. 2015. PMID 25600851 · DOI
  6. Spaans AJ, van Minnen LP, Kon M, Schuurman AH, Schreuders AR, Vermeulen GM. Conservative treatment of thumb base osteoarthritis: a systematic review. J Hand Surg Am. 2015. PMID 25534834 · DOI
  7. Van Heest AE, Kallemeier P. Thumb carpal metacarpal arthritis. J Am Acad Orthop Surg. 2008. PMID 18316712 · DOI
  8. Edmunds JO. Current concepts of the anatomy of the thumb trapeziometacarpal joint. J Hand Surg Am. 2011. PMID 21193137 · DOI
  9. Tang JB, Elliot D, Adani R, Saint-Cyr M, Stang F. Repair and reconstruction of thumb and finger tip injuries: a global view. Clin Plast Surg. 2014. PMID 24996458 · DOI
  10. Moore JS. De Quervain's tenosynovitis. Stenosing tenosynovitis of the first dorsal compartment. J Occup Environ Med. 1997. PMID 9343764 · DOI

About this article

Sources
NLM Medical Subject Headings (definition, synonyms); NCBI PubMed (counts, identifiers); Europe PMC (open-access abstracts and citation counts).
Verification
Every reference was resolved against PubMed on 2026-10-31; title, year and DOI matched.
Review state
automated source verified; no human expert review has been recorded yet.
Version
1, last updated 2026-10-31.

See how EvidenceLib is built. Spotted an error? Email support@evidencehelix.com.

Evidence strength

EvidenceHelix's computed view of the study designs behind this topic: how common meta-analyses, randomized trials and reviews are, how recent the literature is, and a plain-language reading. It describes the design mix of the literature. It is not a quality appraisal of any study, and it is not medical advice.

Included with the Researcher plan

Reading every article stays free. This computed view is part of the paid plans.

See plans Sign in

Your notes

Notes and highlights stay in this browser only; they are not sent to EvidenceHelix.

Related research topics

  • AxillaAnatomy and Physiology
  • ForearmAnatomy and Physiology
  • HandAnatomy and Physiology
  • ShoulderAnatomy and Physiology
  • Upper ExtremityAnatomy and Physiology
  • Abdominal CavityAnatomy and Physiology

All 542 articles in Anatomy and Physiology →

At a glance

10,623
PubMed records on this heading
15%
published since 2020
870
review articles
203
randomized trials
10
verified references below

Counts come from PubMed on 2026-10-31; they show how much has been written, not how strong the evidence is.

Related topics See all →

  • AxillaAnatomy and Physiology
  • ForearmAnatomy and Physiology
  • HandAnatomy and Physiology
  • ShoulderAnatomy and Physiology
  • Upper ExtremityAnatomy and Physiology

My notes & annotations (0)

Nothing yet. Select text and press Highlight, or write a note in the Notes tab. Stored in this browser only.

Sources

  • NLM MeSH record ↗
  • PubMed search used ↗

EvidenceLib is a research-education resource, not medical advice. It does not diagnose, prescribe or recommend starting, stopping or changing any treatment. Talk to a qualified clinician about your own situation. Methods, sources and licences · Legal · Support