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Shoulder

Anatomy and Physiology · NLM MeSH · updated 2026-10-31 · version 1

Citations verified against PubMedNot yet clinician-reviewed10 referencesApproximately 4 min read

Part of the body in humans and primates where the arms connect to the trunk.

Table of Contents

1. Definition2. Research landscape3. Reading the evidence4. Open-access studies5. Key reviews6. References7. About this article

Definition and research guide

This page combines a MeSH definition, publication statistics and selected research abstracts. It is a starting point for reading the literature, not a medical textbook or a systematic evidence review.

Content available: 4 complete abstracts (879 words), 10 references. Full article text is not stored or reproduced here; follow the PMID, DOI or PMC links to read the original sources and their access terms.

Definition

Part of the body in humans and primates where the arms connect to the trunk. The shoulder has five joints; acromioclavicular joint, coracoclavicular joint, glenohumeral joint, scapulathoracic joint, and sternoclavicular joint.

Definition: NLM Medical Subject Headings (MeSH) scope note (Public domain (U.S. National Library of Medicine); attribution requested). View the MeSH record.

Also known as: Shoulders.

Where it fits in the MeSH classification

Broader topics
Upper Extremity

Related concepts

  • Acromioclavicular
  • Coracoclavicular
  • Glenohumeral
  • Sternoclavicular

Research landscape

PubMed indexes 17,210 records tagged with the MeSH heading “Shoulder” (counts retrieved 2026-10-31). 4,323 of them (25.1%) were published from 2020 onward, and the busiest period so far is through 1999 with 6,393 records.

Reviews account for 1,357 records (7.9%) and meta-analyses for 168. Randomized controlled trials number 820 (4.8%) as a share of all records on the topic.

PubMed records by publication periodthrough 1999: 6,393 records; 2000-2009: 2,173 records; 2010-2019: 4,321 records; 2020 onward: 4,323 records6,393through 19992,1732000-20094,3212010-20194,3232020 onward
Records in PubMed indexed with this heading, by publication period. Real counts from NCBI E-utilities; the final period covers only part of the current year. Volume reflects how much has been published, not how strong the evidence is.
Show the data
PeriodRecords
through 19996,393
2000-20092,173
2010-20194,321
2020 onward4,323
Share of records by publication typeReviews: 7.9 percent; Meta-analyses: 1.0 percent; Randomized controlled trials: 4.8 percentReviews7.9% (1,357)Meta-analyses1.0% (168)Randomized controlled trials4.8% (820)
Share of all PubMed records on this heading that carry each publication type. Types overlap with other records, so the shares do not sum to 100%.
Publication-type chart data
Publication types among 17,210 PubMed records
TypeRecordsShare
Reviews1,3577.9%
Meta-analyses1681.0%
Randomized controlled trials8204.8%

Method: PubMed query "Shoulder"[MeSH Terms] with publication-type and date filters, retrieved 2026-10-31.

Reading the evidence in anatomy and physiology

Anatomy describes how body structures are built and physiology describes how they normally work, so most findings here are descriptive or mechanistic rather than evidence about treatment. Much of what is known comes from dissection, imaging, tissue studies and experiments in animals, and measurements in healthy volunteers can differ from those in people with disease or at different ages. Normal ranges vary between individuals and populations. Check whether a result was measured in people or in another species, the age and health of the participants, and the method used.

Evidence from open-access studies

These open-access studies come from PubMed’s best-match results for this heading (papers whose main topic it is), ranked here by citation count, with one recent addition. Each abstract is reproduced in full under its recorded open licence so that you can read the authors’ own words. They illustrate the literature; they are not a systematic summary of it. Citation counts measure attention, not reliability or clinical benefit.

Study comparison — selected abstracts, not a systematic review
Study / authorsYearSource label / designEurope PMC citationsLicence / source
Deep-learning framework and computer assisted fatty infiltration analysis for the supraspinatus muscle in MRI
Ro K, Kim JY, Park H, Cho BH, Kim IY, Shim SB, et al.
2021Research article
Design not recorded in structured metadata
40cc by
PMID 34301978 · DOI · PMC8302634
Subacromial Bursa: A Neglected Tissue Is Gaining More and More Attention in Clinical and Experimental Research
Klatte-Schulz F, Thiele K, Scheibel M, Duda GN, Wildemann B
2022Review article
Design not recorded in structured metadata
33cc by
PMID 35203311 · DOI · PMC8870132
Work above shoulder level and shoulder complaints: a systematic review
Wærsted M, Koch M, Veiersted KB
2020Systematic review
Design not recorded in structured metadata
33cc by
PMID 32572582 · DOI · PMC7519900
Design and Experimental Evaluation of a Shoulder Assistive Exoskeleton for Insulator Replacement
Chen H, Yao J, Li M, Hu H, Yang Z, Tu S, et al.
2026Research article
Design not recorded in structured metadata
0cc by
PMID 42076421 · DOI · PMC13119522

Deep-learning framework and computer assisted fatty infiltration analysis for the supraspinatus muscle in MRI [1]

Research article Ro K, Kim JY, Park H, Cho BH, Kim IY, Shim SB, et al. · · 2021 · cited 40 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
Occupation ratio and fatty infiltration are important parameters for evaluating patients with rotator cuff tears.
Closing excerpt
We expect that this will improve the efficiency and objectivity of diagnoses by quantifying the index used for shoulder MRI.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (287 words)

Occupation ratio and fatty infiltration are important parameters for evaluating patients with rotator cuff tears. We analyzed the occupation ratio using a deep-learning framework and studied the fatty infiltration of the supraspinatus muscle using an automated region-based Otsu thresholding technique. To calculate the amount of fatty infiltration of the supraspinatus muscle using an automated region-based Otsu thresholding technique. The mean Dice similarity coefficient, accuracy, sensitivity, specificity, and relative area difference for the segmented lesion, measuring the similarity of clinician assessment and that of a deep neural network, were 0.97, 99.84, 96.89, 99.92, and 0.07, respectively, for the supraspinatus fossa and 0.94, 99.89, 93.34, 99.95, and 2.03, respectively, for the supraspinatus muscle. The fatty infiltration measure using the Otsu thresholding method significantly differed among the Goutallier grades (Grade 0; 0.06, Grade 1; 4.68, Grade 2; 20.10, Grade 3; 42.86, Grade 4; 55.79, p < 0.0001). The occupation ratio and fatty infiltration using Otsu thresholding demonstrated a moderate negative correlation (ρ = - 0.75, p < 0.0001). This study included 240 randomly selected patients who underwent shoulder magnetic resonance imaging (MRI) from January 2015 to December 2016. We used a fully convolutional deep-learning algorithm to quantitatively detect the fossa and muscle regions by measuring the occupation ratio of the supraspinatus muscle. Fatty infiltration was objectively evaluated using the Otsu thresholding method. The proposed convolutional neural network exhibited fast and accurate segmentation of the supraspinatus muscle and fossa from shoulder MRI, allowing automatic calculation of the occupation ratio. Quantitative evaluation using a modified Otsu thresholding method can be used to calculate the proportion of fatty infiltration in the supraspinatus muscle. We expect that this will improve the efficiency and objectivity of diagnoses by quantifying the index used for shoulder MRI.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 34301978 · DOI · PMC8302634

Subacromial Bursa: A Neglected Tissue Is Gaining More and More Attention in Clinical and Experimental Research [2]

Review article Klatte-Schulz F, Thiele K, Scheibel M, Duda GN, Wildemann B · · 2022 · cited 33 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
The subacromial bursa has long been demolded as friction-reducing tissue, which is often linked to shoulder pain and, therefore, partially removed during shoulder surgery.
Closing excerpt
Increasing attention to tendon repair will help to guide future research and answer open questions such that novel treatment strategies could harvest the subacromial bursa's potential to support healing of nearby rotator cuff injuries.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (200 words)

The subacromial bursa has long been demolded as friction-reducing tissue, which is often linked to shoulder pain and, therefore, partially removed during shoulder surgery. Currently, the discovery of the stem cell potential of resident bursa-derived cells shed a new light on the subacromial bursa. In the meanwhile, this neglected tissue is gaining more attention as to how it can augment the regenerative properties of adjacent tissues such as rotator cuff tendons. Specifically, the tight fibrovascular network, a high growth factor content, and the large progenitor potential of bursa-derived cells could complement the deficits that a nearby rotator cuff injury might experience due to the fact of its low endogenous regeneration potential. This review deals with the question of whether bursal inflammation is only a pain generator or could also be an initiator of healing. Furthermore, several experimental models highlight potential therapeutic targets to overcome bursal inflammation and, thus, pain. More evidence is needed to fully elucidate a direct interplay between subacromial bursa and rotator cuff tendons. Increasing attention to tendon repair will help to guide future research and answer open questions such that novel treatment strategies could harvest the subacromial bursa's potential to support healing of nearby rotator cuff injuries.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 35203311 · DOI · PMC8870132

Work above shoulder level and shoulder complaints: a systematic review [3]

Systematic review Wærsted M, Koch M, Veiersted KB · · 2020 · cited 33 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
ObjectiveTo investigate the association and the exposure-response relationship between work above shoulder height and shoulder pain or disorders.
Closing excerpt
, > 90°) shows a moderate evidence for an association with shoulder disorders.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (219 words)

ObjectiveTo investigate the association and the exposure-response relationship between work above shoulder height and shoulder pain or disorders.MethodsA systematic search was performed in Medline, Embase, and Health and Safety Science Abstracts. Included were articles with prospective cohort, case-control, cross-sectional, or intervention study designs. Quality assessment was based on an evaluation scheme adjusted to study design and normalized to 100%. The cut-off for sufficient quality to include articles was above 40% and cut-off for high-quality articles was above 50% of maximal score. The level of strength of evidence for an association between exposure and effect was assessed according to the GRADE guidelines.ResultsThirty-four articles were included. Articles that document large effects (higher risk estimates; OR ≥ 2) have higher quality score, include analyses of severe arm elevation, more often use clinical outcome, and report an exposure-response relationship compared to studies reporting lower risk estimates. The studies that reported large effects were all significant. An exposure-response relationship was found in many high-quality studies when relating exposure intensity of arm elevation (level of arm elevation, amplitude) as well as duration of arm elevation, especially > 90°.ConclusionWe conclude on a limited evidence for an association between arm elevation at work and shoulder disorders. Severe arm elevation with elbows above shoulder level (i.e., > 90°) shows a moderate evidence for an association with shoulder disorders.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 32572582 · DOI · PMC7519900

Design and Experimental Evaluation of a Shoulder Assistive Exoskeleton for Insulator Replacement [4]

Research article Chen H, Yao J, Li M, Hu H, Yang Z, Tu S, et al. · · 2026

Abstract reading summary — source excerpts
Opening excerpt
Aiming to reduce muscle fatigue and prevent occupational injuries caused by prolonged lifting in insulator replacement operations, this study presents the design of an upper-limb exoskeleton.
Closing excerpt
Experimental results demonstrate that, under a simulated insulator replacement operation with a 20 kg load, the exoskeleton significantly reduces the subject's sEMG activity of the biceps brachii and triceps brachii, effectively alleviating muscle fatigue.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (173 words)

Aiming to reduce muscle fatigue and prevent occupational injuries caused by prolonged lifting in insulator replacement operations, this study presents the design of an upper-limb exoskeleton. Firstly, this study performs kinematic analysis and phase segmentation of the lifting motion in the insulator replacement operation. Based on the analysis, in terms of mechanical structure, the proposed upper-limb exoskeleton adopts a unilateral three-degree-of-freedom shoulder mechanism that biomimics the human glenohumeral joint, which reduces the misalignment between the exoskeleton and the human body. Meanwhile, a waist-back support structure is integrated into the exoskeleton to realize a more reasonable torque transmission path. In terms of the control strategy, based on the operation's phase segmentation and dynamic modeling of the human upper limb, this study develops a neural network-based assistive control algorithm for insulator replacement operations, enabling the exoskeleton to provide phase-specific torque output. Experimental results demonstrate that, under a simulated insulator replacement operation with a 20 kg load, the exoskeleton significantly reduces the subject's sEMG activity of the biceps brachii and triceps brachii, effectively alleviating muscle fatigue.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 42076421 · DOI · PMC13119522

Key reviews and meta-analyses

The most cited review-type papers among PubMed’s best-match results for this heading, listed with bibliographic details only. Follow the links for the full text and access terms.

  • Research article Measuring shoulder function: a systematic review of four questionnaires [5]
    Roy JS, MacDermid JC, Woodhouse LJ · Arthritis Rheum · 2009 · cited 555 times (Europe PMC)
  • Research article Postoperative analgesia for shoulder surgery: a critical appraisal and review of current techniques [6]
    Fredrickson MJ, Krishnan S, Chen CY · Anaesthesia · 2010 · cited 227 times (Europe PMC)
  • Research article Will the Real Benefits of Single-Shot Interscalene Block Please Stand Up? A Systematic Review and Meta-Analysis [7]
    Abdallah FW, Halpern SH, Aoyama K, Brull R · Anesth Analg · 2015 · cited 221 times (Europe PMC)
  • Research article Systematic review of prognostic cohort studies on shoulder disorders [8]
    Kuijpers T, van der Windt DAWM, van der Heijden GJMG, Bouter LM · Pain · 2004 · cited 215 times (Europe PMC)
  • Research article Long head of the biceps tendinopathy: diagnosis and management [9]
    Nho SJ, Strauss EJ, Lenart BA, Provencher MT, Mazzocca AD, Verma NN, et al. · J Am Acad Orthop Surg · 2010 · cited 179 times (Europe PMC)
  • Research article Constant-Murley Score: systematic review and standardized evaluation in different shoulder pathologies [10]
    Vrotsou K, Ávila M, Machón M, Mateo-Abad M, Pardo Y, Garin O, et al. · Qual Life Res · 2018 · cited 150 times (Europe PMC)

References

  1. Ro K, Kim JY, Park H, Cho BH, Kim IY, Shim SB, et al.. Deep-learning framework and computer assisted fatty infiltration analysis for the supraspinatus muscle in MRI. . 2021. PMID 34301978 · DOI · PMC8302634
  2. Klatte-Schulz F, Thiele K, Scheibel M, Duda GN, Wildemann B. Subacromial Bursa: A Neglected Tissue Is Gaining More and More Attention in Clinical and Experimental Research. . 2022. PMID 35203311 · DOI · PMC8870132
  3. Wærsted M, Koch M, Veiersted KB. Work above shoulder level and shoulder complaints: a systematic review. . 2020. PMID 32572582 · DOI · PMC7519900
  4. Chen H, Yao J, Li M, Hu H, Yang Z, Tu S, et al.. Design and Experimental Evaluation of a Shoulder Assistive Exoskeleton for Insulator Replacement. . 2026. PMID 42076421 · DOI · PMC13119522
  5. Roy JS, MacDermid JC, Woodhouse LJ. Measuring shoulder function: a systematic review of four questionnaires. Arthritis Rheum. 2009. PMID 19405008 · DOI
  6. Fredrickson MJ, Krishnan S, Chen CY. Postoperative analgesia for shoulder surgery: a critical appraisal and review of current techniques. Anaesthesia. 2010. PMID 20565394 · DOI
  7. Abdallah FW, Halpern SH, Aoyama K, Brull R. Will the Real Benefits of Single-Shot Interscalene Block Please Stand Up? A Systematic Review and Meta-Analysis. Anesth Analg. 2015. PMID 25822923 · DOI
  8. Kuijpers T, van der Windt DAWM, van der Heijden GJMG, Bouter LM. Systematic review of prognostic cohort studies on shoulder disorders. Pain. 2004. PMID 15157703 · DOI
  9. Nho SJ, Strauss EJ, Lenart BA, Provencher MT, Mazzocca AD, Verma NN, et al.. Long head of the biceps tendinopathy: diagnosis and management. J Am Acad Orthop Surg. 2010. PMID 21041799 · DOI
  10. Vrotsou K, Ávila M, Machón M, Mateo-Abad M, Pardo Y, Garin O, et al.. Constant-Murley Score: systematic review and standardized evaluation in different shoulder pathologies. Qual Life Res. 2018. PMID 29748823 · DOI · PMC6132990

About this article

Sources
NLM Medical Subject Headings (definition, synonyms); NCBI PubMed (counts, identifiers); Europe PMC (open-access abstracts and citation counts).
Verification
Every reference was resolved against PubMed on 2026-10-31; title, year and DOI matched.
Review state
automated source verified; no human expert review has been recorded yet.
Version
1, last updated 2026-10-31.

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All 542 articles in Anatomy and Physiology →

At a glance

17,210
PubMed records on this heading
25%
published since 2020
1,357
review articles
820
randomized trials
10
verified references below

Counts come from PubMed on 2026-10-31; they show how much has been written, not how strong the evidence is.

Related topics See all →

  • AxillaAnatomy and Physiology
  • Upper ExtremityAnatomy and Physiology
  • ForearmAnatomy and Physiology
  • HandAnatomy and Physiology
  • ThumbAnatomy and Physiology

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