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Nasal Septum

Anatomy and Physiology · NLM MeSH · updated 2026-10-31 · version 1

Citations verified against PubMedNot yet clinician-reviewed10 referencesApproximately 5 min read

The partition separating the two nasal cavities in the midplane.

Table of Contents

1. Definition2. Research landscape3. Reading the evidence4. Open-access studies5. Key reviews6. References7. About this article

Definition and research guide

This page combines a MeSH definition, publication statistics and selected research abstracts. It is a starting point for reading the literature, not a medical textbook or a systematic evidence review.

Content available: 4 complete abstracts (935 words), 10 references. Full article text is not stored or reproduced here; follow the PMID, DOI or PMC links to read the original sources and their access terms.

Definition

The partition separating the two nasal cavities in the midplane. It is formed by the septal nasal cartilage, parts of skull bones (ethmoid bone; vomer), and membranous parts.

Definition: NLM Medical Subject Headings (MeSH) scope note (Public domain (U.S. National Library of Medicine); attribution requested). View the MeSH record.

Also known as: Nasal Septums; Septum, Nasal; Septums, Nasal.

Where it fits in the MeSH classification

Broader topics
Nose
Narrower topics
Vomer
See also
Nasal Septal Perforation

Related concepts

  • Nasal Cavity
  • Septal Nasal Cartilage
  • Ethmoid Bone
  • Vomer

Research landscape

PubMed indexes 9,478 records tagged with the MeSH heading “Nasal Septum” (counts retrieved 2026-10-31). 1,704 of them (18.0%) were published from 2020 onward, and the busiest period so far is through 1999 with 3,768 records.

Reviews account for 747 records (7.9%) and meta-analyses for 51. Randomized controlled trials number 261 (2.8%) as a share of all records on the topic.

PubMed records by publication periodthrough 1999: 3,768 records; 2000-2009: 1,624 records; 2010-2019: 2,382 records; 2020 onward: 1,704 records3,768through 19991,6242000-20092,3822010-20191,7042020 onward
Records in PubMed indexed with this heading, by publication period. Real counts from NCBI E-utilities; the final period covers only part of the current year. Volume reflects how much has been published, not how strong the evidence is.
Show the data
PeriodRecords
through 19993,768
2000-20091,624
2010-20192,382
2020 onward1,704
Share of records by publication typeReviews: 7.9 percent; Meta-analyses: 0.5 percent; Randomized controlled trials: 2.8 percentReviews7.9% (747)Meta-analyses0.5% (51)Randomized controlled trials2.8% (261)
Share of all PubMed records on this heading that carry each publication type. Types overlap with other records, so the shares do not sum to 100%.
Publication-type chart data
Publication types among 9,478 PubMed records
TypeRecordsShare
Reviews7477.9%
Meta-analyses510.5%
Randomized controlled trials2612.8%

Method: PubMed query "Nasal Septum"[MeSH Terms] with publication-type and date filters, retrieved 2026-10-31.

Reading the evidence in anatomy and physiology

Anatomy describes how body structures are built and physiology describes how they normally work, so most findings here are descriptive or mechanistic rather than evidence about treatment. Much of what is known comes from dissection, imaging, tissue studies and experiments in animals, and measurements in healthy volunteers can differ from those in people with disease or at different ages. Normal ranges vary between individuals and populations. Check whether a result was measured in people or in another species, the age and health of the participants, and the method used.

Evidence from open-access studies

These open-access studies come from PubMed’s best-match results for this heading (papers whose main topic it is), ranked here by citation count, with one recent addition. Each abstract is reproduced in full under its recorded open licence so that you can read the authors’ own words. They illustrate the literature; they are not a systematic summary of it. Citation counts measure attention, not reliability or clinical benefit.

Study comparison — selected abstracts, not a systematic review
Study / authorsYearSource label / designEurope PMC citationsLicence / source
Complications in septoplasty based on a large group of 5639 patients
Dąbrowska-Bień J, Skarżyński PH, Gwizdalska I, Łazęcka K, Skarżyński H
2018Research article
Design not recorded in structured metadata
58cc by
PMID 29770875 · DOI · PMC5992230
Relationship between the degree and direction of nasal septum deviation and nasal bone morphology
Serifoglu I, Oz İİ, Damar M, Buyukuysal MC, Tosun A, Tokgöz Ö
2017Research article
Design not recorded in structured metadata
35cc by
PMID 28245851 · DOI · PMC5331660
Postoperative otorhinolaryngologic complications in transnasal endoscopic surgery to access the skull base
Dolci RLL, Miyake MM, Tateno DA, Cançado NA, Campos CAC, Dos Santos ARL, et al.
2017Research article
Design not recorded in structured metadata
31cc by
PMID 27320654 · DOI · PMC9444793
The Effectiveness of Functional Septorhinoplasty in Improving COVID-19-related Olfactory Dysfunction
Pendolino AL, Scarpa B, Andrews PJ
2026Research article
Design not recorded in structured metadata
3cc by
PMID 39929248 · DOI · PMC12803777

Complications in septoplasty based on a large group of 5639 patients [1]

Research article Dąbrowska-Bień J, Skarżyński PH, Gwizdalska I, Łazęcka K, Skarżyński H · · 2018 · cited 58 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
PurposeSeptoplasty is a common surgical procedure used for correction of the nasal obstruction caused by a deviated septum.
Closing excerpt
ConclusionsMeticulous attention to detail in identifying the appropriate anatomy and maintaining good visualization is the key to a safe and effective septoplasty, enabling for very low complication rate.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (198 words)

PurposeSeptoplasty is a common surgical procedure used for correction of the nasal obstruction caused by a deviated septum. The aim of the study was to identify complications in septoplasty and analyze incidence depending on the surgical technique, based on the material from 2009 till 2017.MethodsThe material consisted of 5639 medical records from patients aged 16-69, operated in the tertiary referral center. Patients were divided into two groups (2784 exclusively with septoplasty and 2855 with combined septoplasty and turbinoplasty). Z test for the equality of two proportions was made to investigate the assumption that the proportions from two populations are equal, based on two samples, one from each population.ResultsComplications were listed according to international standards. Among the whole study group, different types of complications were noted in 193 patients (3.42%). The most frequent complication was excessive bleeding. Significant differences were observed between the two investigated groups. In patients with combined septoplasty and turbinoplasty septal hematoma, hyposmia, prolonged healing due to infection, adhesions and temporary reduced visual acuity were significantly more often encountered.ConclusionsMeticulous attention to detail in identifying the appropriate anatomy and maintaining good visualization is the key to a safe and effective septoplasty, enabling for very low complication rate.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 29770875 · DOI · PMC5992230

Relationship between the degree and direction of nasal septum deviation and nasal bone morphology [2]

Research article Serifoglu I, Oz İİ, Damar M, Buyukuysal MC, Tosun A, Tokgöz Ö · · 2017 · cited 35 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
BackgroundNasal septal deviation may affect nasal bone growth and facial morphology.
Closing excerpt
ConclusionThe study shows that the direction of nasal septal deviation may be a factor that affects nasal bone morphology.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (263 words)

BackgroundNasal septal deviation may affect nasal bone growth and facial morphology. Knowledge of nasal morphologic parameters may plays an important role in planning successful rhinoplasty and septoplasty operation. The aim of our study was to evaluate the relationship between the direction and degree of nasal septal deviation with nasal bone morphology, along with factors such as age and gender.MethodsMaxillofacial computed tomography (CT) of 250 patients with nasal septal deviation was analyzed retrospectively in this study. We excluded patients with factors that could affect their nasal bone morphology, and a total of 203 patients (111 males, 92 females; mean age, 36.23 years; age range, 18-79 years) were evaluated. The nasal deviation angle was measured on coronal CT images as the angle between the most deviated point of the septum, and the midline nasal morphology was determined by measuring nasal length, internasal angle and lateral and intermediate nasal thickness on both sides.ResultsThe deviation of nasal septum has been detected as to the right in 107 patients (52.7%) and to the left in 96 patients (47.3%). Lateral and intermediate nasal bone thickness and nasal bone length were significantly greater on the ipsilateral deviation side (Table 3). No significant correlation was found between the variation of the nasal deviation angle and nasal bone morphology (Table 4). There were significant differences between the sexes for all investigated parameters except for the nasal deviation angle (p = 0.660). We found that the only internasal angle increases with aging (p = 0.002).ConclusionThe study shows that the direction of nasal septal deviation may be a factor that affects nasal bone morphology.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 28245851 · DOI · PMC5331660

Postoperative otorhinolaryngologic complications in transnasal endoscopic surgery to access the skull base [3]

Research article Dolci RLL, Miyake MM, Tateno DA, Cançado NA, Campos CAC, Dos Santos ARL, et al. · · 2017 · cited 31 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
IntroductionThe large increase in the number of transnasal endoscopic skull base surgeries is a consequence of greater knowledge of the anatomic region, the development of specific materials and instruments, and especially the use of the nasoseptal flap as a barrier between the sinus tract (contaminated cavity) and the subarachnoid space (sterile area), reducing the high risk of contamination.
Closing excerpt
An improvement in this technique is therefore necessary to provide a better quality of life for the patient, reducing potential complications.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (285 words)

IntroductionThe large increase in the number of transnasal endoscopic skull base surgeries is a consequence of greater knowledge of the anatomic region, the development of specific materials and instruments, and especially the use of the nasoseptal flap as a barrier between the sinus tract (contaminated cavity) and the subarachnoid space (sterile area), reducing the high risk of contamination.ObjectiveTo assess the otorhinolaryngologic complications in patients undergoing endoscopic surgery of the skull base, in which a nasoseptal flap was used.MethodsThis was a retrospective study that included patients who underwent endoscopic skull base surgery with creation of a nasoseptal flap, assessing for the presence of the following post-surgical complications: cerebrospinal fluid leak, meningitis, mucocele formation, nasal synechia, septal perforation (prior to posterior septectomy), internal nasal valve failure, epistaxis, and olfactory alterations.ResultsThe study assessed 41 patients undergoing surgery. Of these, 35 had pituitary adenomas (macro- or micro-adenomas; sellar and suprasellar extension), three had meningiomas (two tuberculum sellae and one olfactory groove), two had craniopharyngiomas, and one had an intracranial abscess. The complications were cerebrospinal fluid leak (three patients; 7.3%), meningitis (three patients; 7.3%), nasal fossa synechia (eight patients; 19.5%), internal nasal valve failure (six patients; 14.6%), and complaints of worsening of the sense of smell (16 patients; 39%). The olfactory test showed anosmia or hyposmia in ten patients (24.3%). No patient had mucocele, epistaxis, or septal perforation.ConclusionThe use of the nasoseptal flap has revolutionized endoscopic skull base surgery, making the procedures more effective and with lower morbidity compared to the traditional route. However, although mainly transient nasal morbidities were observed, in some cases, permanent hyposmia and anosmia resulted. An improvement in this technique is therefore necessary to provide a better quality of life for the patient, reducing potential complications.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 27320654 · DOI · PMC9444793

The Effectiveness of Functional Septorhinoplasty in Improving COVID-19-related Olfactory Dysfunction [4]

Research article Pendolino AL, Scarpa B, Andrews PJ · · 2026 · cited 3 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
Long-Term COVID-19-related olfactory dysfunction (C19OD) remains a significant challenge with no established treatment providing meaningful improvement.
Closing excerpt
These findings suggest that fSRP can significantly improve persistent C19OD providing a notable olfactory threshold gain compared to OT.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (189 words)

Long-Term COVID-19-related olfactory dysfunction (C19OD) remains a significant challenge with no established treatment providing meaningful improvement. This study aimed to assess the efficacy of functional septorhinoplasty (fSRP) in improving olfactory dysfunction in patients with persistent C19OD compared to a control group undergoing olfactory training (OT). In this prospective study patients with persistent C19OD undergoing fSRP were enrolled while those declining surgery continued with OT as the control group. Patients were followed for six months with olfactory function assessed using Sniffin' Sticks (S'S) and nasal airflow evaluated through peak nasal inspiratory flow (PNIF) and acoustic rhinometry (AR). Among the participants 12 underwent fSRP while 13 were in the control group. Significant improvements (p < 0.05) in all S'S scores were observed in the fSRP group but not in the control group. TDI scores improved above the minimal clinically important difference only in the fSRP group. Strong correlations were found between olfactory scores and nasal measurements. Comparison of olfactory threshold gains between groups revealed a statistically significant benefit in the fSRP group. These findings suggest that fSRP can significantly improve persistent C19OD providing a notable olfactory threshold gain compared to OT.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 39929248 · DOI · PMC12803777

Key reviews and meta-analyses

The most cited review-type papers among PubMed’s best-match results for this heading, listed with bibliographic details only. Follow the links for the full text and access terms.

  • Research article Neurobehavioral evidence for the involvement of the vomeronasal system in mammalian reproduction [5]
    Wysocki CJ · Neurosci Biobehav Rev · 1979 · cited 310 times (Europe PMC)
  • Research article Current status of grafts and implants in rhinoplasty: part I. Autologous grafts [6]
    Sajjadian A, Rubinstein R, Naghshineh N · Plast Reconstr Surg · 2010 · cited 127 times (Europe PMC)
  • Research article Surgical nuances for nasoseptal flap reconstruction of cranial base defects with high-flow cerebrospinal fluid leaks after endoscopic skull base surgery [7]
    Liu JK, Schmidt RF, Choudhry OJ, Shukla PA, Eloy JA · Neurosurg Focus · 2012 · cited 102 times (Europe PMC)
  • Research article Different surgical treatments for nasal septal perforation and their outcomes [8]
    Goh AY, Hussain SS · J Laryngol Otol · 2007 · cited 82 times (Europe PMC)
  • Research article Nasal, septal, and turbinate anatomy and embryology [9]
    Neskey D, Eloy JA, Casiano RR · Otolaryngol Clin North Am · 2009 · cited 79 times (Europe PMC)
  • Research article Considerations in the etiology, treatment, and repair of septal perforations [10]
    Kridel RW · Facial Plast Surg Clin North Am · 2004 · cited 73 times (Europe PMC)

References

  1. Dąbrowska-Bień J, Skarżyński PH, Gwizdalska I, Łazęcka K, Skarżyński H. Complications in septoplasty based on a large group of 5639 patients. . 2018. PMID 29770875 · DOI · PMC5992230
  2. Serifoglu I, Oz İİ, Damar M, Buyukuysal MC, Tosun A, Tokgöz Ö. Relationship between the degree and direction of nasal septum deviation and nasal bone morphology. . 2017. PMID 28245851 · DOI · PMC5331660
  3. Dolci RLL, Miyake MM, Tateno DA, Cançado NA, Campos CAC, Dos Santos ARL, et al.. Postoperative otorhinolaryngologic complications in transnasal endoscopic surgery to access the skull base. . 2017. PMID 27320654 · DOI · PMC9444793
  4. Pendolino AL, Scarpa B, Andrews PJ. The Effectiveness of Functional Septorhinoplasty in Improving COVID-19-related Olfactory Dysfunction. . 2026. PMID 39929248 · DOI · PMC12803777
  5. Wysocki CJ. Neurobehavioral evidence for the involvement of the vomeronasal system in mammalian reproduction. Neurosci Biobehav Rev. 1979. PMID 396492 · DOI
  6. Sajjadian A, Rubinstein R, Naghshineh N. Current status of grafts and implants in rhinoplasty: part I. Autologous grafts. Plast Reconstr Surg. 2010. PMID 19910845 · DOI
  7. Liu JK, Schmidt RF, Choudhry OJ, Shukla PA, Eloy JA. Surgical nuances for nasoseptal flap reconstruction of cranial base defects with high-flow cerebrospinal fluid leaks after endoscopic skull base surgery. Neurosurg Focus. 2012. PMID 22655696 · DOI
  8. Goh AY, Hussain SS. Different surgical treatments for nasal septal perforation and their outcomes. J Laryngol Otol. 2007. PMID 17250780 · DOI
  9. Neskey D, Eloy JA, Casiano RR. Nasal, septal, and turbinate anatomy and embryology. Otolaryngol Clin North Am. 2009. PMID 19328886 · DOI
  10. Kridel RW. Considerations in the etiology, treatment, and repair of septal perforations. Facial Plast Surg Clin North Am. 2004. PMID 15337112 · DOI

About this article

Sources
NLM Medical Subject Headings (definition, synonyms); NCBI PubMed (counts, identifiers); Europe PMC (open-access abstracts and citation counts).
Verification
Every reference was resolved against PubMed on 2026-10-31; title, year and DOI matched.
Review state
automated source verified; no human expert review has been recorded yet.
Version
1, last updated 2026-10-31.

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Related research topics

  • Nasal CavityAnatomy and Physiology
  • Sphenoid SinusAnatomy and Physiology
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  • Frontal BoneAnatomy and Physiology
  • EpiglottisAnatomy and Physiology
  • Hyoid BoneAnatomy and Physiology

All 542 articles in Anatomy and Physiology →

At a glance

9,478
PubMed records on this heading
18%
published since 2020
747
review articles
261
randomized trials
10
verified references below

Counts come from PubMed on 2026-10-31; they show how much has been written, not how strong the evidence is.

Related topics See all →

  • Nasal CavityAnatomy and Physiology
  • Sphenoid SinusAnatomy and Physiology
  • Hyaline CartilageAnatomy and Physiology
  • Frontal BoneAnatomy and Physiology
  • EpiglottisAnatomy and Physiology

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