Definition and research guide
This page combines a MeSH definition, publication statistics and selected research abstracts. It is a starting point for reading the literature, not a medical textbook or a systematic evidence review.
Content available: 4 complete abstracts (882 words), 10 references. Full article text is not stored or reproduced here; follow the PMID, DOI or PMC links to read the original sources and their access terms.
Definition
A hernia-like condition in which the weakened pelvic muscles cause the urinary bladder to drop from its normal position. Fallen urinary bladder is more common in females with the bladder dropping into the vagina and less common in males with the bladder dropping into the scrotum.
Definition: NLM Medical Subject Headings (MeSH) scope note (Public domain (U.S. National Library of Medicine); attribution requested). View the MeSH record.
Also known as: Fallen Urinary Bladder; Urinary Bladder Prolapse; Prolapse, Urinary Bladder.
Where it fits in the MeSH classification
- Broader topics
- Urinary Bladder Diseases; Pelvic Organ Prolapse
Related concepts
- Hernia-
- Urinary Bladder
- Vagina
- Scrotum
Research landscape
PubMed indexes 635 records tagged with the MeSH heading “Cystocele” (counts retrieved 2026-11-04). 107 of them (16.9%) were published from 2020 onward, and the busiest period so far is 2010-2019 with 296 records.
Reviews account for 44 records (6.9%) and meta-analyses for 3. Randomized controlled trials number 33 (5.2%) as a share of all records on the topic.
Show the data
| Period | Records |
|---|---|
| through 1999 | 54 |
| 2000-2009 | 178 |
| 2010-2019 | 296 |
| 2020 onward | 107 |
Publication-type chart data
| Type | Records | Share |
|---|---|---|
| Reviews | 44 | 6.9% |
| Meta-analyses | 3 | 0.5% |
| Randomized controlled trials | 33 | 5.2% |
Method: PubMed query "Cystocele"[MeSH Terms] with publication-type and date filters, retrieved 2026-11-04.
Reading the evidence in kidney, urology and women's health
Kidney, urinary and reproductive health research uses lab markers (such as creatinine), imaging, symptom scores and registry data on pregnancy and birth. Findings about pregnancy are especially sensitive to who was studied and when in pregnancy exposure occurred. Nothing on this page is advice about treatment, fertility or pregnancy; speak to a qualified clinician. Check the population, the outcome measured and whether the study accounted for other health differences between groups.
Evidence from open-access studies
These open-access studies come from PubMed’s best-match results for this heading (papers whose main topic it is), ranked here by citation count, with one recent addition. Each abstract is reproduced in full under its recorded open licence so that you can read the authors’ own words. They illustrate the literature; they are not a systematic summary of it. Citation counts measure attention, not reliability or clinical benefit.
| Study / authors | Year | Source label / design | Europe PMC citations | Licence / source |
|---|---|---|---|---|
| Pelvic organ prolapse in nulliparae | 2022 | Research article Design not recorded in structured metadata | 9 | cc by PMID 35048356 · DOI · PMC9305753 |
| Perineal ultrasound as a complement to POP-Q in the assessment of cystoceles | 2014 | Research article Design not recorded in structured metadata | 9 | cc by PMID 25525602 · DOI · PMC4265551 |
| Genital prolapse: epidemiology, clinic and therapeutic at Saint Joseph Hospital of Kinshasa | 2020 | Research article Design not recorded in structured metadata | 6 | cc by PMID 33505565 · DOI · PMC7813651 |
| Is Midline Uterosacral Plication Anterior Colporrhaphy Combo (MUSPACC) Procedure a Good Option in Management of Vaginal Vault Prolapse and Cystocele? | 2026 | Research article Design not recorded in structured metadata | 0 | cc by PMID 42075581 · DOI · PMC13117828 |
Pelvic organ prolapse in nulliparae [1]
Abstract reading summary — source excerpts
- Opening excerpt
- BackgroundPregnancy and childbirth are thought to be the strongest environmental risk factors for pelvic organ prolapse, but prolapse does occur in nulliparae.
- Closing excerpt
- Pregnancy and caesarean delivery seem to have little effect.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (253 words)
BackgroundPregnancy and childbirth are thought to be the strongest environmental risk factors for pelvic organ prolapse, but prolapse does occur in nulliparae.AimTo characterise prolapse in vaginal nulliparae.Material and methodsThis was a retrospective study using archived clinical and imaging data of 368 vaginally nulliparous women seen between 2006 and 2017 at two tertiary urogynaecological centres. Patients underwent a standardised interview, clinical examination and 3D/4D translabial ultrasound. Volume datasets were analysed by the second author, blinded against all clinical data, using post-processing software on a personal computer. Significant prolapse was defined as Pelvic Organ Prolapse Quantification system stage ≥2 for the anterior and posterior compartment, and stage ≥1 for the central compartment. On imaging, significant prolapse was defined as previously described.ResultsOf 4297 women seen during the inclusion period, 409 were vaginally nulliparous, for whom 368 volume data sets could be retrieved. Mean age was 50 years (17-89) and mean body mass index 29 (16-64). Eighty-one (22%) presented with prolapse symptoms. On clinical examination, 106 women (29%) had significant prolapse, mostly of the posterior compartment (n = 70, 19%). On imaging 64 women showed evidence of significant prolapse (17%), again mostly posterior (n = 47, 13%). Rectovaginal septal defects were even more common in 69 (19%). On multivariate analysis we found no differences between true nulliparae (n = 184) and women delivered exclusively by caesarean section (n = 184).ConclusionsProlapse occurs in vaginal nulliparae, but it has distinct characteristics. Rectocele predominates, while cystocele and uterine prolapse are uncommon. Pregnancy and caesarean delivery seem to have little effect.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 35048356 · DOI · PMC9305753
Perineal ultrasound as a complement to POP-Q in the assessment of cystoceles [2]
Abstract reading summary — source excerpts
- Opening excerpt
- PurposeIn the present study we want to propose a classification system to quantify cystoceles by perineal ultrasound (PUS).
- Closing excerpt
- Further studies are needed to evaluate the clinical use of the classification system proposed here.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (195 words)
PurposeIn the present study we want to propose a classification system to quantify cystoceles by perineal ultrasound (PUS).Materials and methods120 PUS data were analyzed measuring the distance between the lowest point of the bladder and the midpubic line (MPL) during rest and Valsalva. Results were classified into groups and compared to POP-Q using the κ-coefficient. Results for exact bladder position were checked for interrater reliability using ICC and Pearson's coefficient and results for classification were checked using the κ-coefficient. Bladder positions at rest and Valsalva were correlated with the distance between these points.ResultsHighly significant differences concerning the position at rest and the distance between rest and Valsalva were found between the groups. For the interrater agreement, the Pearson correlation coefficient was ρ = 0.98, the ICC (A-1) = 0.98, and κ = 1.00. Comparing the classification results for POP-Q and PUS, the kappa-coefficient was κ = 0.65.ConclusionPUS using the MPL and the classification system is a highly reliable tool for the evaluation of cystoceles. PUS shows good correlation with POP-Q. Furthermore, PUS offers a doubtless identification of the descending organ. Further studies are needed to evaluate the clinical use of the classification system proposed here.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 25525602 · DOI · PMC4265551
Genital prolapse: epidemiology, clinic and therapeutic at Saint Joseph Hospital of Kinshasa [3]
Abstract reading summary — source excerpts
- Opening excerpt
- The aim of the study was to describe the epidemiological, clinical and therapeutical profile of genital prolapse in the gynecology and obstetrics service of Saint Joseph Hospital of Kinshasa.
- Closing excerpt
- The genital prolapse really exist in our milieu, its symptomatology is classical and its treatment is mostly surgical by vaginal access.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (175 words)
The aim of the study was to describe the epidemiological, clinical and therapeutical profile of genital prolapse in the gynecology and obstetrics service of Saint Joseph Hospital of Kinshasa. This is a descriptive study carried out from medical files of patients who have suffered from genital prolapse in the gynecology and obstetrics service of Saint Joseph Hospital from January 1st, 2008 to December 31st, 2017. It is based on the no probabilistic sampling of suitability. We recorded 161 cases of genital prolapses upon 13957 patients. The genital prolapses frequency was 1.2% with an annual average of 16.1 cases (SD 10.1) per year. The symptomatology consisted of pelvic mass associated with urinary and digestives troubles (94.0%, n=140). The stage III of cysto-colpocele was the most frequent (56.0%, n=82). The vaginal hysterectomy associated to rectocele and cystocele cure was the most performed operation (52.0%, n=69). The recurrence rate was of 2.0% (3 out of 148 cases). The genital prolapse really exist in our milieu, its symptomatology is classical and its treatment is mostly surgical by vaginal access.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 33505565 · DOI · PMC7813651
Is Midline Uterosacral Plication Anterior Colporrhaphy Combo (MUSPACC) Procedure a Good Option in Management of Vaginal Vault Prolapse and Cystocele? [4]
Abstract reading summary — source excerpts
- Opening excerpt
- Background and Objectives: After the publication by Haylen et al.
- Closing excerpt
- Routine perioperative cystoscopy is now performed for immediate detection and management of urinary tract injuries.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (259 words)
Background and Objectives: After the publication by Haylen et al. introducing the MUSPACC (midline uterosacral plication anterior colporrhaphy combination) procedure, we implemented this technique in our clinical practice for the treatment of cystocele and vaginal vault prolapse (VVP). The aims of this study were to evaluate peri- and postoperative complications, as well as vaginal and urinary symptoms, including patient satisfaction 3 months postoperatively. Materials and Methods: A retrospective analysis was conducted on 58 women who underwent MUSPACC over a five-year period. Patient-reported outcomes were assessed using three prolapse-related items from the International Consultation on Incontinence-Vaginal Symptoms (ICIQ-VS) and the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI SF), administered preoperatively and at three months following surgery. Demographic characteristics, as well as perioperative and postoperative complications, were obtained through review of medical records. Results: At follow-up, patients demonstrated improvement in vaginal symptoms, with the mean preoperative ICIQ-VS score decreasing from 15.2 to 1.16. Among those with preoperative urinary incontinence (UI), 42.1% became completely dry after MUSPACC procedure alone. Three patients (15%) developed de novo UI. Perioperative complications occurred in one patient. The postoperative complication rate was 20.7% (12/58), including one patient who experienced a postoperative fistula between the right ureter and vagina. No further surgeries were required. Overall, 96.4% of patients were satisfied postoperatively. Conclusions: MUSPACC procedure appears to be an effective treatment for VVP and cystocele, with improvement in vaginal and urinary symptoms, high patient satisfaction, and a low rate of serious complications. Routine perioperative cystoscopy is now performed for immediate detection and management of urinary tract injuries.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 42075581 · DOI · PMC13117828
Key reviews and meta-analyses
The most cited review-type papers among PubMed’s best-match results for this heading, listed with bibliographic details only. Follow the links for the full text and access terms.
- Research article Alterations in connective tissue metabolism in stress incontinence and prolapse [5]
- Research article ACOG Practice Bulletin No. 85: Pelvic organ prolapse [6]
- Research article Prosthetic surgery versus native tissue repair of cystocele: literature review [7]
- Research article Cystocele and functional anatomy of the pelvic floor: review and update of the various theories [8]
- Research article Surgical treatment of pelvic organ prolapse: a historical review with emphasis on the anterior compartment [9]
- Research article Anterior vaginal compartment surgery [10]
References
- Dietz HP, Chavez-Coloma L, Friedman T, Turel F. Pelvic organ prolapse in nulliparae. . 2022. PMID 35048356 · DOI · PMC9305753
- Najjari L, Hennemann J, Larscheid P, Papathemelis T, Maass N. Perineal ultrasound as a complement to POP-Q in the assessment of cystoceles. . 2014. PMID 25525602 · DOI · PMC4265551
- Kayembe AT, Muela AM, Baleka AM, Mushengezi DS, Tozin RR. Genital prolapse: epidemiology, clinic and therapeutic at Saint Joseph Hospital of Kinshasa. . 2020. PMID 33505565 · DOI · PMC7813651
- Ugianskiene A, Juhl CS, Glavind K. Is Midline Uterosacral Plication Anterior Colporrhaphy Combo (MUSPACC) Procedure a Good Option in Management of Vaginal Vault Prolapse and Cystocele?. . 2026. PMID 42075581 · DOI · PMC13117828
- Chen B, Yeh J. Alterations in connective tissue metabolism in stress incontinence and prolapse. J Urol. 2011. PMID 21944102 · DOI
- ACOG Committee on Practice Bulletins--Gynecology. ACOG Practice Bulletin No. 85: Pelvic organ prolapse. Obstet Gynecol. 2007. PMID 17766624 · DOI
- Vitale SG, Laganà AS, Gulino FA, Tropea A, Tarda S. Prosthetic surgery versus native tissue repair of cystocele: literature review. Updates Surg. 2016. PMID 26801794 · DOI
- Lamblin G, Delorme E, Cosson M, Rubod C. Cystocele and functional anatomy of the pelvic floor: review and update of the various theories. Int Urogynecol J. 2016. PMID 26337427 · DOI
- Lensen EJ, Withagen MI, Kluivers KB, Milani AL, Vierhout ME. Surgical treatment of pelvic organ prolapse: a historical review with emphasis on the anterior compartment. Int Urogynecol J. 2013. PMID 23494056 · DOI
- Maher C. Anterior vaginal compartment surgery. Int Urogynecol J. 2013. PMID 24142055 · DOI
About this article
- Sources
- NLM Medical Subject Headings (definition, synonyms); NCBI PubMed (counts, identifiers); Europe PMC (open-access abstracts and citation counts).
- Verification
- Every reference was resolved against PubMed on 2026-11-04; title, year and DOI matched.
- Review state
- automated source verified; no human expert review has been recorded yet.
- Version
- 1, last updated 2026-11-04.
See how EvidenceLib is built. Spotted an error? Email support@evidencehelix.com.
Evidence strength
EvidenceHelix's computed view of the study designs behind this topic: how common meta-analyses, randomized trials and reviews are, how recent the literature is, and a plain-language reading. It describes the design mix of the literature. It is not a quality appraisal of any study, and it is not medical advice.