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Astigmatism

Eye, Ear, Nose and Throat · NLM MeSH · updated 2026-11-04 · version 1

Citations verified against PubMedNot yet clinician-reviewed10 referencesApproximately 4 min read

Unequal or irregular curvature of the cornea (Corneal astigmatism) and/or the eye lens (Lenticular astigmatism) resulting in refractive error.

Table of Contents

1. Definition2. Research landscape3. Reading the evidence4. Open-access studies5. Key reviews6. References7. About this article

Definition and research guide

This page combines a MeSH definition, publication statistics and selected research abstracts. It is a starting point for reading the literature, not a medical textbook or a systematic evidence review.

Content available: 4 complete abstracts (788 words), 10 references. Full article text is not stored or reproduced here; follow the PMID, DOI or PMC links to read the original sources and their access terms.

Definition

Unequal or irregular curvature of the cornea (Corneal astigmatism) and/or the eye lens (Lenticular astigmatism) resulting in refractive error.

Definition: NLM Medical Subject Headings (MeSH) scope note (Public domain (U.S. National Library of Medicine); attribution requested). View the MeSH record.

Also known as: Corneal Astigmatism; Astigmatism, Corneal; Lenticular Astigmatism; Astigmatism, Lenticular; Oblique Astigmatism; Astigmatism, Oblique; Oblique Astigmatisms; Myopic Astigmatism.

Where it fits in the MeSH classification

Broader topics
Refractive Errors

Related concepts

  • Cornea
  • Eye Lens
  • Refractive Error

Research landscape

PubMed indexes 8,778 records tagged with the MeSH heading “Astigmatism” (counts retrieved 2026-11-04). 1,692 of them (19.3%) were published from 2020 onward, and the busiest period so far is through 1999 with 2,883 records.

Reviews account for 445 records (5.1%) and meta-analyses for 56. Randomized controlled trials number 477 (5.4%) as a share of all records on the topic.

PubMed records by publication periodthrough 1999: 2,883 records; 2000-2009: 1,936 records; 2010-2019: 2,267 records; 2020 onward: 1,692 records2,883through 19991,9362000-20092,2672010-20191,6922020 onward
Records in PubMed indexed with this heading, by publication period. Real counts from NCBI E-utilities; the final period covers only part of the current year. Volume reflects how much has been published, not how strong the evidence is.
Show the data
PeriodRecords
through 19992,883
2000-20091,936
2010-20192,267
2020 onward1,692
Share of records by publication typeReviews: 5.1 percent; Meta-analyses: 0.6 percent; Randomized controlled trials: 5.4 percentReviews5.1% (445)Meta-analyses0.6% (56)Randomized controlled trials5.4% (477)
Share of all PubMed records on this heading that carry each publication type. Types overlap with other records, so the shares do not sum to 100%.
Publication-type chart data
Publication types among 8,778 PubMed records
TypeRecordsShare
Reviews4455.1%
Meta-analyses560.6%
Randomized controlled trials4775.4%

Method: PubMed query "Astigmatism"[MeSH Terms] with publication-type and date filters, retrieved 2026-11-04.

Reading the evidence in eye, ear, nose and throat

Eye, hearing, nose and throat studies rely on specialist tests (visual acuity, eye pressure, audiograms, scopes) and on patient-reported symptoms, which vary between people and with age. Some conditions improve without treatment, so comparison groups matter. Nothing on this page is advice about diagnosis or treatment; sudden loss of sight or hearing needs urgent care from a qualified clinician. Check how the outcome was tested, the age of the people studied and how long they were followed.

Evidence from open-access studies

These open-access studies come from PubMed’s best-match results for this heading (papers whose main topic it is), ranked here by citation count, with one recent addition. Each abstract is reproduced in full under its recorded open licence so that you can read the authors’ own words. They illustrate the literature; they are not a systematic summary of it. Citation counts measure attention, not reliability or clinical benefit.

Study comparison — selected abstracts, not a systematic review
Study / authorsYearSource label / designEurope PMC citationsLicence / source
Refractive outcomes of small lenticule extraction (SMILE) Pro® with a 2 MHz femtosecond laser
Saad A, Klabe K, Kirca M, Kretz FAT, Auffarth G, Breyer DRH
2024Research article
Design not recorded in structured metadata
33cc by
PMID 38340212 · DOI · PMC10858925
mEYEstro software: an automatic tool for standardized refractive surgery outcomes reporting
Gauvin M, Wallerstein A
2023Research article
Design not recorded in structured metadata
28cc by
PMID 37085797 · DOI · PMC10120175
Refractive error and vision related quality of life
Rajabpour M, Kangari H, Pesudovs K, Khorrami-Nejad M, Rahmani S, Mohaghegh S, et al.
2024Research article
Design not recorded in structured metadata
23cc by
PMID 38388340 · DOI · PMC10885569
Effects of SMILE on intraocular pressure and corneal biomechanics: a systematic review and meta-analysis
Lampsas S, Chardalia GM, Karmiris E, Kymionis GD, Chatziralli I
2026Meta-analysis
Design not recorded in structured metadata
0cc by
PMID 42635859 · DOI · PMC13503405

Refractive outcomes of small lenticule extraction (SMILE) Pro® with a 2 MHz femtosecond laser [1]

Research article Saad A, Klabe K, Kirca M, Kretz FAT, Auffarth G, Breyer DRH · · 2024 · cited 33 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
PurposeTo evaluate the initial visual outcomes of Small Incision Lenticule Extraction (SMILE) Pro® using a 2 MHz femtosecond laser (VisuMax 800, Carl Zeiss Meditec) and to assess the efficacy, safety, predictability, accuracy, and complication rate.
Closing excerpt
No complications were recorded in our patients.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (245 words)

PurposeTo evaluate the initial visual outcomes of Small Incision Lenticule Extraction (SMILE) Pro® using a 2 MHz femtosecond laser (VisuMax 800, Carl Zeiss Meditec) and to assess the efficacy, safety, predictability, accuracy, and complication rate.MethodsThis retrospective analysis included eyes which underwent the SMILE Pro® procedure using VisuMax 800 femtosecond laser to correct myopia. All surgeries were performed by one surgeon (DB). Follow-up was conducted 3 months postoperatively to evaluate visual outcomes after neuroadaptation, corrected visual acuity (CDVA) and intra- and postoperative complications.ResultsOne hundred and fifty-two eyes of 82 patients (mean age 31 ± 6 years) results at 3 months are presented. The mean spherical equivalent (SE) was - 4.44 ± 1.86 D preoperatively while -0.24 ± 0.32 D postoperatively. 99% of eyes achieved SE within ± 1.0 D of attempted correction and 91% were within ± 0.5 D. Efficacy index was 0.93 while the safety index was 1. No complications occurred intra- or postoperatively. No eyes lost more than 1 line of their preoperative CDVA. All highly myopic eyes (- 6.25 to - 10.00 D; n = 18) achieved 20/20 at 3 months postoperatively and were within 0.5 D from the attempted SE and no eyes lost more than 1 line of CDVA.ConclusionThe SMILE Pro® is a safe, efficient, and predictable procedure for the treatment of myopia and myopic astigmatism, with comparable results of conventional SMILE surgery. High myopic eyes achieve better results than low and moderate myopia. No complications were recorded in our patients.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 38340212 · DOI · PMC10858925

mEYEstro software: an automatic tool for standardized refractive surgery outcomes reporting [2]

Research article Gauvin M, Wallerstein A · · 2023 · cited 28 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
BackgroundStandardization for reporting medical outcomes enables clinical study comparisons and has a fundamental role in research reproducibility.
Closing excerpt
ConclusionsmEYEstro software enables clinicians, surgeons, and researchers, to easily and efficiently analyze refractive surgery outcomes using the standardized methodology required by several peer-reviewed ophthalmology journals.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (209 words)

BackgroundStandardization for reporting medical outcomes enables clinical study comparisons and has a fundamental role in research reproducibility. In this context, we present mEYEstro, a free novel standalone application for automated standardized refractive surgery graphs. mEYEstro can be used for single and multiple group comparisons in corneal and intraocular refractive surgery patients. In less than 30 s and with minimal user manipulation, mEYEstro automatically creates the required journal standard graphs while simultaneously performing valid statistical analyses.ResultsThe software produces the following 11 standard graphs; Efficacy: 1. Cumulative uncorrected (UDVA) and corrected visual acuity (CDVA), 2. Difference between UDVA and CDVA, Safety: 3. Change in line of CDVA, Accuracy: 4. Spherical equivalent (SEQ) to intended target, 5. Attempted vs. achieved SEQ, 6. Defocus equivalent (DEQ) accuracy, 7. Refractive astigmatism accuracy, 8. Target-induced astigmatism vs. Surgically-induced astigmatism, 9. Correction index histogram, 10. Angle of error histogram, Stability: 11. SEQ stability over time. Percent proportions, means, standard deviations, Cohen's d effect sizes, and p-values are calculated and displayed on each graph. All graphs can be easily exported as high-resolution TIFF images for figures to use in scientific manuscripts and presentations.ConclusionsmEYEstro software enables clinicians, surgeons, and researchers, to easily and efficiently analyze refractive surgery outcomes using the standardized methodology required by several peer-reviewed ophthalmology journals.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 37085797 · DOI · PMC10120175

Refractive error and vision related quality of life [3]

Research article Rajabpour M, Kangari H, Pesudovs K, Khorrami-Nejad M, Rahmani S, Mohaghegh S, et al. · · 2024 · cited 23 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
BackgroundTo investigate and compare the vision-related quality of life (QOL) in different types of refractive error (RE).
Closing excerpt
Therefore, it is strongly recommended not to neglect managing very low myopia since it may improve participants' QOL.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (145 words)

BackgroundTo investigate and compare the vision-related quality of life (QOL) in different types of refractive error (RE).MethodsThis cross-sectional study was performed on 200 subjects, categorized into four groups of 50 each, consisting of subjects with myopia, hyperopia, astigmatism, and emmetropia, the latter being the control group. The mean age of the participants was 23.88 ± 5.87 (range, 15 to 38: 110 females and 90 males). RE was defined as myopia, spherical equivalent (SE) + 0.25 D, astigmatism, cylinder ResultsCorrected myopia, astigmatism, uncorrected myopia, and hyperopia had a lower vision-related QOL than emmetropes. (P ConclusionIndividuals with refractive errors experience a lower QOL score than those without. Notably, the adverse impact on QOL score is significantly greater in myopic cases, particularly very low myopia, compared to other refractive errors. Therefore, it is strongly recommended not to neglect managing very low myopia since it may improve participants' QOL.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 38388340 · DOI · PMC10885569

Effects of SMILE on intraocular pressure and corneal biomechanics: a systematic review and meta-analysis [4]

Meta-analysis Lampsas S, Chardalia GM, Karmiris E, Kymionis GD, Chatziralli I · · 2026

Abstract reading summary — source excerpts
Opening excerpt
PurposeSmall incision lenticule extraction (SMILE) is a popular flapless refractive procedure for myopia and myopic astigmatism, although postoperative corneal biomechanical changes may affect intraocular pressure measurements and glaucoma assessment.
Closing excerpt
Clinicians should interpret postoperative IOP values cautiously, even when using biomechanically corrected tonometric devices.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (189 words)

PurposeSmall incision lenticule extraction (SMILE) is a popular flapless refractive procedure for myopia and myopic astigmatism, although postoperative corneal biomechanical changes may affect intraocular pressure measurements and glaucoma assessment. This systematic review and meta-analysis aimed to quantify the postoperative underestimation of IOP and changes in corneal biomechanical parameters following SMILE.Materials and methodsA comprehensive literature search of PubMed, Cochrane Library, ScienceDirect, and Scopus databases was performed up to April 30, 2026, according to PRISMA guidelines. Observational studies reporting preoperative and postoperative IOP measurements after SMILE using Goldmann applanation tonometry (GAT), Ocular Response Analyzer (ORA), or Corvis ST were included. Secondary outcomes included changes in corneal hysteresis (CH) and corneal resistance factor (CRF).ResultsSeventeen studies involving 1177 eyes were analyzed. Postoperative IOP was significantly reduced across all tonometric modalities. The pooled mean reduction was greatest with GAT (MD: 3.47 mmHg; 95% CI 2.85-4.10), followed by ORA (MD: 2.50 mmHg; 95% CI 2.06-2.94) and Corvis ST (MD: 1.52 mmHg; 95% CI 0.62-2.42) (all p ConclusionsSMILE leads to significant underestimation of IOP measurements and measurable biomechanical weakening of the cornea. Clinicians should interpret postoperative IOP values cautiously, even when using biomechanically corrected tonometric devices.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 42635859 · DOI · PMC13503405

Key reviews and meta-analyses

The most cited review-type papers among PubMed’s best-match results for this heading, listed with bibliographic details only. Follow the links for the full text and access terms.

  • Research article Toric Intraocular Lenses in the Correction of Astigmatism During Cataract Surgery: A Systematic Review and Meta-analysis [5]
    Kessel L, Andresen J, Tendal B, Erngaard D, Flesner P, Hjortdal J · Ophthalmology · 2016 · cited 282 times (Europe PMC)
  • Research article A review of astigmatism and its possible genesis [6]
    Read SA, Collins MJ, Carney LG · Clin Exp Optom · 2007 · cited 210 times (Europe PMC)
  • Research article Toric intraocular lenses: historical overview, patient selection, IOL calculation, surgical techniques, clinical outcomes, and complications [7]
    Visser N, Bauer NJ, Nuijts RM · J Cataract Refract Surg · 2013 · cited 204 times (Europe PMC)
  • Research article Practical astigmatism analysis for refractive outcomes in cataract and refractive surgery [8]
    Alpins NA, Goggin M · Surv Ophthalmol · 2004 · cited 153 times (Europe PMC)
  • Research article CLEAR - Orthokeratology [9]
    Vincent SJ, Cho P, Chan KY, Fadel D, Ghorbani-Mojarrad N, González-Méijome JM, et al. · Cont Lens Anterior Eye · 2021 · cited 143 times (Europe PMC)
  • Research article Astigmatism and toric intraocular lenses [10]
    Novis C · Curr Opin Ophthalmol · 2000 · cited 133 times (Europe PMC)

References

  1. Saad A, Klabe K, Kirca M, Kretz FAT, Auffarth G, Breyer DRH. Refractive outcomes of small lenticule extraction (SMILE) Pro® with a 2 MHz femtosecond laser. . 2024. PMID 38340212 · DOI · PMC10858925
  2. Gauvin M, Wallerstein A. mEYEstro software: an automatic tool for standardized refractive surgery outcomes reporting. . 2023. PMID 37085797 · DOI · PMC10120175
  3. Rajabpour M, Kangari H, Pesudovs K, Khorrami-Nejad M, Rahmani S, Mohaghegh S, et al.. Refractive error and vision related quality of life. . 2024. PMID 38388340 · DOI · PMC10885569
  4. Lampsas S, Chardalia GM, Karmiris E, Kymionis GD, Chatziralli I. Effects of SMILE on intraocular pressure and corneal biomechanics: a systematic review and meta-analysis. . 2026. PMID 42635859 · DOI · PMC13503405
  5. Kessel L, Andresen J, Tendal B, Erngaard D, Flesner P, Hjortdal J. Toric Intraocular Lenses in the Correction of Astigmatism During Cataract Surgery: A Systematic Review and Meta-analysis. Ophthalmology. 2016. PMID 26601819 · DOI
  6. Read SA, Collins MJ, Carney LG. A review of astigmatism and its possible genesis. Clin Exp Optom. 2007. PMID 17177660 · DOI
  7. Visser N, Bauer NJ, Nuijts RM. Toric intraocular lenses: historical overview, patient selection, IOL calculation, surgical techniques, clinical outcomes, and complications. J Cataract Refract Surg. 2013. PMID 23522584 · DOI
  8. Alpins NA, Goggin M. Practical astigmatism analysis for refractive outcomes in cataract and refractive surgery. Surv Ophthalmol. 2004. PMID 14711444 · DOI
  9. Vincent SJ, Cho P, Chan KY, Fadel D, Ghorbani-Mojarrad N, González-Méijome JM, et al.. CLEAR - Orthokeratology. Cont Lens Anterior Eye. 2021. PMID 33775379 · DOI
  10. Novis C. Astigmatism and toric intraocular lenses. Curr Opin Ophthalmol. 2000. PMID 10724827 · DOI

About this article

Sources
NLM Medical Subject Headings (definition, synonyms); NCBI PubMed (counts, identifiers); Europe PMC (open-access abstracts and citation counts).
Verification
Every reference was resolved against PubMed on 2026-11-04; title, year and DOI matched.
Review state
automated source verified; no human expert review has been recorded yet.
Version
1, last updated 2026-11-04.

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At a glance

8,778
PubMed records on this heading
19%
published since 2020
445
review articles
477
randomized trials
10
verified references below

Counts come from PubMed on 2026-11-04; they show how much has been written, not how strong the evidence is.

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