Definition and research guide
This page combines a MeSH definition, publication statistics and selected research abstracts. It is a starting point for reading the literature, not a medical textbook or a systematic evidence review.
Content available: 4 complete abstracts (1,132 words), 10 references. Full article text is not stored or reproduced here; follow the PMID, DOI or PMC links to read the original sources and their access terms.
Definition
The maintenance of certain aspects of the environment within a defined space to facilitate the function of that space; aspects controlled include air temperature and motion, radiant heat level, moisture, and concentration of pollutants such as dust, microorganisms, and gases. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Definition: NLM Medical Subject Headings (MeSH) scope note (Public domain (U.S. National Library of Medicine); attribution requested). View the MeSH record.
Also known as: Air Conditionings; Conditioning, Air; Conditionings, Air; Air Revitalization; Air Revitalizations; Revitalization, Air; Revitalizations, Air; Climate Control.
Where it fits in the MeSH classification
- Broader topics
- Environment, Controlled
Research landscape
PubMed indexes 2,991 records tagged with the MeSH heading “Air Conditioning” (counts retrieved 2026-10-31). 350 of them (11.7%) were published from 2020 onward, and the busiest period so far is through 1999 with 1,546 records.
Reviews account for 190 records (6.4%) and meta-analyses for 5. Randomized controlled trials number 32 (1.1%) as a share of all records on the topic. Randomized trials make up only a small share of this literature, so much of what is known comes from laboratory, observational or descriptive work.
Show the data
| Period | Records |
|---|---|
| through 1999 | 1,546 |
| 2000-2009 | 560 |
| 2010-2019 | 535 |
| 2020 onward | 350 |
Publication-type chart data
| Type | Records | Share |
|---|---|---|
| Reviews | 190 | 6.4% |
| Meta-analyses | 5 | 0.2% |
| Randomized controlled trials | 32 | 1.1% |
Method: PubMed query "Air Conditioning"[MeSH Terms] with publication-type and date filters, retrieved 2026-10-31.
Reading the evidence in public health and nutrition
Population and nutrition studies mostly observe what people eat, breathe or are exposed to and then look for links with health, which shows association and not proof of cause. Self-reported diet is imprecise, people who eat or live differently also differ in other ways, and effects measured across a population may not apply to one person. Check the study design, how exposure was measured, what else was accounted for and the size of the effect, not only whether it was statistically significant.
Evidence from open-access studies
These open-access studies come from PubMed’s best-match results for this heading (papers whose main topic it is), ranked here by citation count, with one recent addition. Each abstract is reproduced in full under its recorded open licence so that you can read the authors’ own words. They illustrate the literature; they are not a systematic summary of it. Citation counts measure attention, not reliability or clinical benefit.
| Study / authors | Year | Source label / design | Europe PMC citations | Licence / source |
|---|---|---|---|---|
| Air conditioning and source-specific particles as modifiers of the effect of PM(10) on hospital admissions for heart and lung disease | 2002 | Research article Design not recorded in structured metadata | 143 | cc by PMID 11781164 · DOI · PMC1240692 |
| Can Air-Conditioning Systems Contribute to the Spread of SARS/MERS/COVID-19 Infection? Insights from a Rapid Review of the Literature | 2020 | Review article Design not recorded in structured metadata | 57 | cc by PMID 32825303 · DOI · PMC7503634 |
| Heating, ventilation and air conditioning (HVAC) in intensive care unit | 2020 | Review article Design not recorded in structured metadata | 48 | cc by PMID 32375844 · DOI · PMC7201115 |
| Air Conditioning in Nursing Homes and Mortality During Extreme Heat | 2026 | Research article Design not recorded in structured metadata | 4 | cc by PMID 41396588 · DOI · PMC12706679 |
Air conditioning and source-specific particles as modifiers of the effect of PM(10) on hospital admissions for heart and lung disease [1]
Abstract reading summary — source excerpts
- Opening excerpt
- Studies on acute effects of particulate matter (PM) air pollution show significant variability in exposure-effect relations among cities.
- Closing excerpt
- The results suggest that air conditioning and proportion of especially traffic-related particles significantly modify the effect of PM(10) on hospital admissions, especially for CVD.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (263 words)
Studies on acute effects of particulate matter (PM) air pollution show significant variability in exposure-effect relations among cities. Recent studies have shown an influence of ventilation on personal/indoor-outdoor relations and stronger associations of adverse effects with combustion-related particles. We evaluated whether differences in prevalence of air conditioning (AC) and/or the contribution of different sources to total PM(10) emissions could partly explain the observed variability in exposure-effect relations. We used regression coefficients of the relation between PM(10) and hospital admissions for chronic obstructive pulmonary disease (COPD), cardiovascular disease (CVD), and pneumonia from a recent study in 14 U.S. cities. We obtained data on the prevalence of AC from the 1993 American Housing Survey and data on PM(10) emissions by source category, vehicle miles traveled (VMT), and population density from the U.S. EPA. We analyzed data using meta-regression techniques. PM(10) regression coefficients for CVD and COPD decreased significantly with increasing percentage of homes with central AC when cities were stratified by whether their PM(10) concentrations peaked in winter or non-winter months. PM(10) coefficients for CVD increased significantly with increasing percentage of PM(10) emission from highway vehicles, highway diesels, oil combustion, metal processing, decreasing percentage of PM(10) emission from fugitive dust, and increasing population density and VMT/mile(2). In multivariate analysis, only percentage of PM(subscript)10(/subscript) from highway vehicles/diesels and oil combustion remained significant. For COPD and pneumonia, associations were less significant but the patterns of the associations were similar to that for CVD. The results suggest that air conditioning and proportion of especially traffic-related particles significantly modify the effect of PM(10) on hospital admissions, especially for CVD.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 11781164 · DOI · PMC1240692
Can Air-Conditioning Systems Contribute to the Spread of SARS/MERS/COVID-19 Infection? Insights from a Rapid Review of the Literature [2]
Abstract reading summary — source excerpts
- Opening excerpt
- The airborne transmission of SARS-CoV-2 is still debated.
- Closing excerpt
- The few COVID-19 investigations available do not provide sufficient evidence that the SARS-CoV-2 virus can be transmitted by HVAC systems.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (255 words)
The airborne transmission of SARS-CoV-2 is still debated. The aim of this rapid review is to evaluate the COVID-19 risk associated with the presence of air-conditioning systems. Original studies (both observational and experimental researches) written in English and with no limit on time, on the airborne transmission of SARS-CoV, MERS-CoV, and SARS-CoV-2 coronaviruses that were associated with outbreaks, were included. Searches were made on PubMed/MEDLINE, PubMed Central (PMC), Google Scholar databases, and medRxiv. A snowball strategy was adopted to extend the search. Fourteen studies reporting outbreaks of coronavirus infection associated with the air-conditioning systems were included. All studies were carried out in the Far East. In six out the seven studies on SARS, the role of Heating, Ventilation, and Air Conditioning (HVAC) in the outbreak was indirectly proven by the spatial and temporal pattern of cases, or by airflow-dynamics models. In one report on MERS, the contamination of HVAC by viral particles was demonstrated. In four out of the six studies on SARS-CoV-2, the diffusion of viral particles through HVAC was suspected or supported by computer simulation. In conclusion, there is sufficient evidence of the airborne transmission of coronaviruses in previous Asian outbreaks, and this has been taken into account in the guidelines released by organizations and international agencies for controlling the spread of SARS-CoV-2 in indoor environments. However, the technological differences in HVAC systems prevent the generalization of the results on a worldwide basis. The few COVID-19 investigations available do not provide sufficient evidence that the SARS-CoV-2 virus can be transmitted by HVAC systems.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 32825303 · DOI · PMC7503634
Heating, ventilation and air conditioning (HVAC) in intensive care unit [3]
Abstract reading summary — source excerpts
- Opening excerpt
- The aim of this review is to describe variation in standards and guidelines on 'heating, ventilation and air-conditioning (HVAC)' system maintenance in the intensive care units, across the world, which is required to maintain good 'indoor air quality' as an important non-pharmacological strategy in preventing hospital-acquired infections.
- Closing excerpt
- In summary, there is a need of universal standards for HVAC system with a specific mention on the type of ICU, which should be incorporated into existing infection control practice guidelines.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (188 words)
The aim of this review is to describe variation in standards and guidelines on 'heating, ventilation and air-conditioning (HVAC)' system maintenance in the intensive care units, across the world, which is required to maintain good 'indoor air quality' as an important non-pharmacological strategy in preventing hospital-acquired infections. An online search and review of standards and guidelines published by various societies including American Institute of Architects (AIA), American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE), Centers for Disease Control and Prevention (CDC), Department of Health Estates and Facilities Division, Health Technical Memorandum 2025 (HTM) and Healthcare Infection Control Practices Advisory Committee (HICPAC) along with various national expert committee consensus statements, regional and hospital-based protocols available in a public domain were retrieved. Selected publications and textbooks describing HVAC structural aspects were also reviewed, and we described the basic structural details of HVAC system as well as variations in the practised standards of HVAC system in the ICU, worldwide. In summary, there is a need of universal standards for HVAC system with a specific mention on the type of ICU, which should be incorporated into existing infection control practice guidelines.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 32375844 · DOI · PMC7201115
Air Conditioning in Nursing Homes and Mortality During Extreme Heat [4]
Abstract reading summary — source excerpts
- Opening excerpt
- ImportanceExtreme heat poses a serious health risk to older adults because they are generally more susceptible to heat-related mortality.
- Closing excerpt
- These findings suggest that AC provision in nursing homes and other congregate care settings may be important for preventing mortality among older adults during extreme heat days.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (426 words)
ImportanceExtreme heat poses a serious health risk to older adults because they are generally more susceptible to heat-related mortality. Many nursing homes in the US and elsewhere lack air conditioning (AC). Ecological studies have evaluated the protective role of AC against mortality on extreme heat days in prisons and large urban settings; however, the nursing home setting remains understudied.ObjectiveTo assess mortality rates during extreme heat days in nursing homes with AC compared to those without AC.Design, setting, and participantsThis was a case-crossover study conducted in Ontario, Canada, to determine the odds of mortality associated with extreme days separated for nursing homes with and without AC using conditional logistic regression. Nursing home residents who died during the warm months (June to September) from 2010 to 2023 were included. Data were analyzed from June 2024 to April 2025.ExposuresAn extreme heat day was defined as any day in the ≥90th percentile of the heat index (ambient temperature and relative humidity) for any given nursing home location during the study period.Main outcomes and measuresAll-cause mortality during extreme heat days, by AC status of nursing homes.ResultsOf the 73 578 deaths of nursing home residents from 2010 to 2023, 40 255 residents (mean [SD] age, 86.8 [8.8] years; 65.6% women) died at 276 homes with AC and 33 323 residents (mean [SD] age, 87.2 [8.7] years; 64.8% women) at 339 homes without AC. Before the AC mandate was announced in July 2020, nursing homes without AC (55.1%) were predominantly investor owned (ie, for profit; standardized mean difference [SMD], 0.47), were built to older design standards (SMD, 0.57), and had more residents per room (SMD, 0.58) compared with nursing homes with AC. Overall, 4889 deaths (13.8%) in nursing homes without AC occurred on extreme heat days compared with 4611 deaths (12.1%) in those with AC. Extreme heat was associated with significantly increased odds of mortality in nursing homes without AC (odds ratio [OR], 1.11; 95% CI, 1.06-1.16) but not in those with AC (OR, 1.03; 95% CI, 0.98-1.07). Compared to nursing homes with AC, those without AC were associated with significantly higher relative odds of mortality on extreme heat days (relative OR, 1.08; 95% CI, 1.01-1.15). Lagged analyses suggest that the associated effects of extreme heat persisted for 3 days beyond the initial exposure.Conclusion and relevanceIn this case-crossover study, mortality was lower during extreme heat days in nursing homes with AC compared to those without AC. These findings suggest that AC provision in nursing homes and other congregate care settings may be important for preventing mortality among older adults during extreme heat days.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 41396588 · DOI · PMC12706679
Key reviews and meta-analyses
The most cited review-type papers among PubMed’s best-match results for this heading, listed with bibliographic details only. Follow the links for the full text and access terms.
- Research article Reducing the health effects of hot weather and heat extremes: from personal cooling strategies to green cities [5]
- Research article Air-conditioning in the human nasal cavity [6]
- Research article Assessing the environmental health relevance of cooling towers--a systematic review of legionellosis outbreaks [7]
- Research article Role of mechanical ventilation in the airborne transmission of infectious agents in buildings [8]
- Research article Back to Normal: An Old Physics Route to Reduce SARS-CoV-2 Transmission in Indoor Spaces [9]
- Research article Effect of air filtration systems on asthma: a systematic review of randomized trials [10]
References
- Janssen NA, Schwartz J, Zanobetti A, Suh HH. Air conditioning and source-specific particles as modifiers of the effect of PM(10) on hospital admissions for heart and lung disease. . 2002. PMID 11781164 · DOI · PMC1240692
- Chirico F, Sacco A, Bragazzi NL, Magnavita N. Can Air-Conditioning Systems Contribute to the Spread of SARS/MERS/COVID-19 Infection? Insights from a Rapid Review of the Literature. . 2020. PMID 32825303 · DOI · PMC7503634
- Saran S, Gurjar M, Baronia A, Sivapurapu V, Ghosh PS, Raju GM, et al.. Heating, ventilation and air conditioning (HVAC) in intensive care unit. . 2020. PMID 32375844 · DOI · PMC7201115
- Katz GM, Brown KA, Giannakeas V, Stall NM. Air Conditioning in Nursing Homes and Mortality During Extreme Heat. . 2026. PMID 41396588 · DOI · PMC12706679
- Jay O, Capon A, Capon A, Berry P, Broderick C, de Dear R, et al.. Reducing the health effects of hot weather and heat extremes: from personal cooling strategies to green cities. Lancet. 2021. PMID 34419206 · DOI
- Elad D, Wolf M, Keck T. Air-conditioning in the human nasal cavity. Respir Physiol Neurobiol. 2008. PMID 18565805 · DOI
- Walser SM, Gerstner DG, Brenner B, Höller C, Liebl B, Herr CE. Assessing the environmental health relevance of cooling towers--a systematic review of legionellosis outbreaks. Int J Hyg Environ Health. 2014. PMID 24100053 · DOI
- Luongo JC, Fennelly KP, Keen JA, Zhai ZJ, Jones BW, Miller SL. Role of mechanical ventilation in the airborne transmission of infectious agents in buildings. Indoor Air. 2016. PMID 26562748 · DOI · PMC7165552
- García de Abajo FJ, Hernández RJ, Kaminer I, Meyerhans A, Rosell-Llompart J, Sanchez-Elsner T. Back to Normal: An Old Physics Route to Reduce SARS-CoV-2 Transmission in Indoor Spaces. ACS Nano. 2020. PMID 32551537 · DOI
- McDonald E, Cook D, Newman T, Griffith L, Cox G, Guyatt G. Effect of air filtration systems on asthma: a systematic review of randomized trials. Chest. 2002. PMID 12426250 · DOI
About this article
- Sources
- NLM Medical Subject Headings (definition, synonyms); NCBI PubMed (counts, identifiers); Europe PMC (open-access abstracts and citation counts).
- Verification
- Every reference was resolved against PubMed on 2026-11-04; title, year and DOI matched.
- Review state
- automated source verified; no human expert review has been recorded yet.
- Version
- 1, last updated 2026-11-04.
See how EvidenceLib is built. Spotted an error? Email support@evidencehelix.com.
Evidence strength
EvidenceHelix's computed view of the study designs behind this topic: how common meta-analyses, randomized trials and reviews are, how recent the literature is, and a plain-language reading. It describes the design mix of the literature. It is not a quality appraisal of any study, and it is not medical advice.