Definition and research guide
This page combines a MeSH definition, publication statistics and selected research abstracts. It is a starting point for reading the literature, not a medical textbook or a systematic evidence review.
Content available: 4 complete abstracts (869 words), 10 references. Full article text is not stored or reproduced here; follow the PMID, DOI or PMC links to read the original sources and their access terms.
Definition
The frequency of different ages or age groups in a given population. The distribution may refer to either how many or what proportion of the group. The population is usually patients with a specific disease but the concept is not restricted to humans and is not restricted to medicine.
Definition: NLM Medical Subject Headings (MeSH) scope note (Public domain (U.S. National Library of Medicine); attribution requested). View the MeSH record.
Also known as: Age Distributions; Distribution, Age; Distributions, Age.
Where it fits in the MeSH classification
- Broader topics
- Demography
Research landscape
PubMed indexes 70,048 records tagged with the MeSH heading “Age Distribution” (counts retrieved 2026-10-31). 3,846 of them (5.5%) were published from 2020 onward, and the busiest period so far is 2000-2009 with 29,601 records.
Reviews account for 4,602 records (6.6%) and meta-analyses for 497. Randomized controlled trials number 593 (0.8%) as a share of all records on the topic. Randomized trials make up only a small share of this literature, so much of what is known comes from laboratory, observational or descriptive work.
Show the data
| Period | Records |
|---|---|
| through 1999 | 10,921 |
| 2000-2009 | 29,601 |
| 2010-2019 | 25,680 |
| 2020 onward | 3,846 |
Publication-type chart data
| Type | Records | Share |
|---|---|---|
| Reviews | 4,602 | 6.6% |
| Meta-analyses | 497 | 0.7% |
| Randomized controlled trials | 593 | 0.8% |
Method: PubMed query "Age Distribution"[MeSH Terms] with publication-type and date filters, retrieved 2026-10-31.
Reading the evidence in public health and nutrition
Population and nutrition studies mostly observe what people eat, breathe or are exposed to and then look for links with health, which shows association and not proof of cause. Self-reported diet is imprecise, people who eat or live differently also differ in other ways, and effects measured across a population may not apply to one person. Check the study design, how exposure was measured, what else was accounted for and the size of the effect, not only whether it was statistically significant.
Evidence from open-access studies
These open-access studies come from PubMed’s best-match results for this heading (papers whose main topic it is), ranked here by citation count, with one recent addition. Each abstract is reproduced in full under its recorded open licence so that you can read the authors’ own words. They illustrate the literature; they are not a systematic summary of it. Citation counts measure attention, not reliability or clinical benefit.
| Study / authors | Year | Source label / design | Europe PMC citations | Licence / source |
|---|---|---|---|---|
| COVID-19 Pandemic: Age-Related Differences in Measures of Stress, Anxiety and Depression in Canada | 2020 | Research article Design not recorded in structured metadata | 187 | cc by PMID 32882922 · DOI · PMC7503671 |
| Why is There Low Morbidity and Mortality of COVID-19 in Africa? | 2020 | Research article Design not recorded in structured metadata | 132 | cc by PMID 32484156 · DOI · PMC7410455 |
| Health literacy among different age groups in Germany: results of a cross-sectional survey | 2016 | Research article Design not recorded in structured metadata | 119 | cc by PMID 27829401 · DOI · PMC5103460 |
| Quality of reported ages: A robust re-modification in Total Modified Whipple's Index | 2025 | Research article Design not recorded in structured metadata | 0 | cc by PMID 40845135 · DOI · PMC12373282 |
COVID-19 Pandemic: Age-Related Differences in Measures of Stress, Anxiety and Depression in Canada [1]
Abstract reading summary — source excerpts
- Opening excerpt
- BackgroundThe spread of COVID-19 along with strict public health measures have resulted in unintended adverse effects, including greater levels of distress, anxiety, and depression.
- Closing excerpt
- ConclusionsThe finding that the prevalence rates and the mean scores for stress, anxiety, and depression on standardized scales to decrease from younger to older subscribers is an interesting observation with potential implications for planning to meet mental health service needs during COVID-19.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (202 words)
BackgroundThe spread of COVID-19 along with strict public health measures have resulted in unintended adverse effects, including greater levels of distress, anxiety, and depression. This study examined relative presentations of these psychopathologies in different age groups in a Canadian cohort during the COVID-19 pandemic.MethodologyParticipants were subscribers to the Text4Hope program, developed to support Albertans during the COVID-19 pandemic. A survey link was used to gather demographic information and responses on several self-report scales, such as Perceived Stress Scale (PSS), Generalized Anxiety Disorder 7-item (GAD-7) scale, and Patient Health Questionnaire-9 (PHQ-9).ResultsThere were 8267 individuals who completed the survey, giving a response rate of 19.4%. Overall, 909 (11.0%) respondents identified as ≤25 years, 2939 (35.6%) identified as (26-40) years, 3431 (41.5%) identified as (41-60) years, 762 (9.2%) identified as over 60 years, and 226 (2.7%) did not identify their age. Mean scores on the PSS, GAD-7, and PHQ-9 scales were highest among those aged ≤25 and lowest amongst those aged >60 years old.ConclusionsThe finding that the prevalence rates and the mean scores for stress, anxiety, and depression on standardized scales to decrease from younger to older subscribers is an interesting observation with potential implications for planning to meet mental health service needs during COVID-19.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 32882922 · DOI · PMC7503671
Why is There Low Morbidity and Mortality of COVID-19 in Africa? [2]
Abstract reading summary — source excerpts
- Opening excerpt
- Three months since the detection of the first COVID-19 case in Africa, almost all countries of the continent continued to report lower morbidity and mortality than the global trend, including Europe and North America.
- Closing excerpt
- Having a youthful population and favorable weather appears compelling, particularly their combined effect; however, progression of the pandemic in the region and globally may dispel these in the coming months.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (98 words)
Three months since the detection of the first COVID-19 case in Africa, almost all countries of the continent continued to report lower morbidity and mortality than the global trend, including Europe and North America. We reviewed the merits of various hypotheses advanced to explain this phenomenon, including low seeding rate, effective mitigation measures, population that is more youthful, favorable weather, and possible prior exposure to a cross-reactive virus. Having a youthful population and favorable weather appears compelling, particularly their combined effect; however, progression of the pandemic in the region and globally may dispel these in the coming months.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 32484156 · DOI · PMC7410455
Health literacy among different age groups in Germany: results of a cross-sectional survey [3]
Abstract reading summary — source excerpts
- Opening excerpt
- BackgroundHealth literacy is of increasing importance in public health research.
- Closing excerpt
- Particular attention should be devoted to persons with lower social status, limited functional health literacy and/or a high number of doctor visits in all age groups.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (244 words)
BackgroundHealth literacy is of increasing importance in public health research. It is a necessary pre-condition for the involvement in decisions about health and health care and related to health outcomes. Knowledge about limited health literacy in different age groups is crucial to better target public health interventions for subgroups of the population. However, little is known about health literacy in Germany. The study therefore assesses the prevalence of limited health literacy and associated factors among different age groups.MethodsThe Health Literacy Survey Germany is a cross-sectional study with 2,000 participants aged 15 years or older in private households. Perceived health literacy was assessed via computer-assisted personal interviews using the HLS-EU-Q-47 questionnaire. Descriptive analyses, chi-square tests and odds ratios were performed stratified for different age groups.ResultsThe population affected by limited perceived health literacy increases by age. Of the respondents aged 15-29 years, 47.3 % had limited perceived health literacy and 47.2 % of those aged 30-45 years, whereas 55.2 % of the respondents aged 46-64 years and 66.4 % aged 65 years and older showed limited perceived health literacy. In all age groups, limited perceived health literacy was associated with limited functional health literacy, low social status, and a high frequency of doctor visits.ConclusionsThe results suggest a need to further investigate perceived health literacy in all phases of the life-course. Particular attention should be devoted to persons with lower social status, limited functional health literacy and/or a high number of doctor visits in all age groups.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 27829401 · DOI · PMC5103460
Quality of reported ages: A robust re-modification in Total Modified Whipple's Index [4]
Abstract reading summary — source excerpts
- Opening excerpt
- In demographic research, the accuracy of the reported ages in surveys and censuses is a persistently important issue.
- Closing excerpt
- The proposed modification is suitable for the evaluation of the quality of self reported and interviewer recorded ages at the time of surveys and censuses.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (325 words)
In demographic research, the accuracy of the reported ages in surveys and censuses is a persistently important issue. The common indices developed and used to examine the quality of age data are Whipple, Myers, Bachi's, modified Whipple, and the total modified Whipple's index. The most commonly used and simplest to compute index is the original Whipple's index proposed by George Chandler Whipple. It is a summary measure used to check age heaping on ages ending with digits 0 and 5. The other summary index is the total modified Whipple index by Spoorenberg. A robust modification is proposed for the total modified Whipple index. This modification, based on the method of the original Whipple index for all digits (0, 1, 2 … 9), is simple, robust, and easy to interpret. The proposed index is used to check the quality of age data from the Demographic and Health Survey data series of three countries (India, Pakistan, and Turkey). The original Whipple index only measures the preferences or avoidances of ages ending in digits 0 and 5. The existing summary index total modified Whipple index, based on modified Whipple indexes, covers all ages; however, results showed that the digit indexes for the terminal digits 1, 2, 3 and 4 have some added probability of being included. The newly proposed summary index, Robust Modified Whipple Index, is based on Rogers Whipple indexes, which display an equal probability for all ten digits i = 1,2,3…,9. In the application to the series of datasets, the proposed index is found better and more robust. The comparison of the results of the total modified Whipple index and proposed robust modified Whipple index concludes that the proposed modification is a more precise and robust to measure age misreporting by taking the effects of all terminal digits of reported ages. The proposed modification is suitable for the evaluation of the quality of self reported and interviewer recorded ages at the time of surveys and censuses.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 40845135 · DOI · PMC12373282
Key reviews and meta-analyses
The most cited review-type papers among PubMed’s best-match results for this heading, listed with bibliographic details only. Follow the links for the full text and access terms.
- Research article Birth cohort trends in the global epidemiology of alcohol use and alcohol-related harms in men and women: systematic review and metaregression [5]
- Research article The effect of age on susceptibility to hypoxic-ischemic brain damage [6]
- Research article Cancer burden with ageing population in urban regions in China: projection on cancer registry data from World Health Organization [7]
- Research article [Age and migration--an overview] [8]
- Research article Systematic Review: Distribution of Age and Intervention Modalities in Therapeutic Clinical Trials for Autism Spectrum Disorder [9]
- Research article [Cardiovascular system and aging] [10]
References
- Nwachukwu I, Nkire N, Shalaby R, Hrabok M, Vuong W, Gusnowski A, et al.. COVID-19 Pandemic: Age-Related Differences in Measures of Stress, Anxiety and Depression in Canada. . 2020. PMID 32882922 · DOI · PMC7503671
- Njenga MK, Dawa J, Nanyingi M, Gachohi J, Ngere I, Letko M, et al.. Why is There Low Morbidity and Mortality of COVID-19 in Africa?. . 2020. PMID 32484156 · DOI · PMC7410455
- Berens EM, Vogt D, Messer M, Hurrelmann K, Schaeffer D. Health literacy among different age groups in Germany: results of a cross-sectional survey. . 2016. PMID 27829401 · DOI · PMC5103460
- Rasul A, Nasir JA, Jasilionis D, Jdanov DA. Quality of reported ages: A robust re-modification in Total Modified Whipple's Index. . 2025. PMID 40845135 · DOI · PMC12373282
- Slade T, Chapman C, Swift W, Keyes K, Tonks Z, Teesson M. Birth cohort trends in the global epidemiology of alcohol use and alcohol-related harms in men and women: systematic review and metaregression. BMJ Open. 2016. PMID 27797998 · DOI · PMC5093369
- Yager JY, Thornhill JA. The effect of age on susceptibility to hypoxic-ischemic brain damage. Neurosci Biobehav Rev. 1997. PMID 9062939 · DOI
- Tsoi KK, Hirai HW, Chan FC, Griffiths S, Sung JJ. Cancer burden with ageing population in urban regions in China: projection on cancer registry data from World Health Organization. Br Med Bull. 2017. PMID 27913398 · DOI
- Schopf C, Naegele G. [Age and migration--an overview]. Z Gerontol Geriatr. 2005. PMID 16362554 · DOI
- Lewis AS, van Schalkwyk GI. Systematic Review: Distribution of Age and Intervention Modalities in Therapeutic Clinical Trials for Autism Spectrum Disorder. J Autism Dev Disord. 2020. PMID 30815774 · DOI · PMC6711831
- Saner H. [Cardiovascular system and aging]. Ther Umsch. 2005. PMID 16405288 · DOI
About this article
- Sources
- NLM Medical Subject Headings (definition, synonyms); NCBI PubMed (counts, identifiers); Europe PMC (open-access abstracts and citation counts).
- Verification
- Every reference was resolved against PubMed on 2026-11-04; title, year and DOI matched.
- Review state
- automated source verified; no human expert review has been recorded yet.
- Version
- 1, last updated 2026-11-04.
See how EvidenceLib is built. Spotted an error? Email support@evidencehelix.com.
Evidence strength
EvidenceHelix's computed view of the study designs behind this topic: how common meta-analyses, randomized trials and reviews are, how recent the literature is, and a plain-language reading. It describes the design mix of the literature. It is not a quality appraisal of any study, and it is not medical advice.