Definition and research guide
This page combines a MeSH definition, publication statistics and selected research abstracts. It is a starting point for reading the literature, not a medical textbook or a systematic evidence review.
Content available: 4 complete abstracts (1,140 words), 10 references. Full article text is not stored or reproduced here; follow the PMID, DOI or PMC links to read the original sources and their access terms.
Definition
The joint that is formed by the inferior articular and malleolar articular surfaces of the tibia; the malleolar articular surface of the fibula; and the medial malleolar, lateral malleolar, and superior surfaces of the talus.
Definition: NLM Medical Subject Headings (MeSH) scope note (Public domain (U.S. National Library of Medicine); attribution requested). View the MeSH record.
Also known as: Ankle Joints; Joint, Ankle; Joints, Ankle; Ankle Syndesmosis; Ankle Syndesmoses; Syndesmosis, Ankle; Articulatio talocruralis; Talocrural Joint.
Where it fits in the MeSH classification
- Broader topics
- Foot Joints
- See also
- Ankle
Related concepts
Research landscape
PubMed indexes 22,172 records tagged with the MeSH heading “Ankle Joint” (counts retrieved 2026-10-31). 6,289 of them (28.4%) were published from 2020 onward, and the busiest period so far is 2010-2019 with 7,395 records.
Reviews account for 2,208 records (10.0%) and meta-analyses for 249. Randomized controlled trials number 858 (3.9%) as a share of all records on the topic.
Show the data
| Period | Records |
|---|---|
| through 1999 | 4,930 |
| 2000-2009 | 3,558 |
| 2010-2019 | 7,395 |
| 2020 onward | 6,289 |
Publication-type chart data
| Type | Records | Share |
|---|---|---|
| Reviews | 2,208 | 10.0% |
| Meta-analyses | 249 | 1.1% |
| Randomized controlled trials | 858 | 3.9% |
Method: PubMed query "Ankle Joint"[MeSH Terms] with publication-type and date filters, retrieved 2026-10-31.
Reading the evidence in anatomy and physiology
Anatomy describes how body structures are built and physiology describes how they normally work, so most findings here are descriptive or mechanistic rather than evidence about treatment. Much of what is known comes from dissection, imaging, tissue studies and experiments in animals, and measurements in healthy volunteers can differ from those in people with disease or at different ages. Normal ranges vary between individuals and populations. Check whether a result was measured in people or in another species, the age and health of the participants, and the method used.
Evidence from open-access studies
These open-access studies come from PubMed’s best-match results for this heading (papers whose main topic it is), ranked here by citation count, with one recent addition. Each abstract is reproduced in full under its recorded open licence so that you can read the authors’ own words. They illustrate the literature; they are not a systematic summary of it. Citation counts measure attention, not reliability or clinical benefit.
| Study / authors | Year | Source label / design | Europe PMC citations | Licence / source |
|---|---|---|---|---|
| Effect of proprioceptive neuromuscular facilitation on patients with chronic ankle instability: A systematic review and meta-analysis | 2025 | Meta-analysis Design not recorded in structured metadata | 16 | cc by PMID 39787087 · DOI · PMC11717224 |
| Effectiveness of exercise therapy on chronic ankle instability: a meta-analysis | 2025 | Meta-analysis Design not recorded in structured metadata | 13 | cc by PMID 40188228 · DOI · PMC11972327 |
| Impact of specialized fatigue and backhand smash on the ankle biomechanics of female badminton players | 2024 | Research article Design not recorded in structured metadata | 10 | cc by PMID 38704481 · DOI · PMC11069527 |
| Mental Health Predictors of Dynamic Balance in Individuals With Chronic Ankle Instability | 2026 | Research article Design not recorded in structured metadata | 0 | cc by PMID 41913085 · DOI · PMC13581079 |
Effect of proprioceptive neuromuscular facilitation on patients with chronic ankle instability: A systematic review and meta-analysis [1]
Abstract reading summary — source excerpts
- Opening excerpt
- ObjectiveThis study conducts a rigorous meta-analysis of existing literature to rigorously examine the efficacy of Proprioceptive Neuromuscular Facilitation (PNF) in ameliorating functional deficits associated with Chronic Ankle Instability (CAI).
- Closing excerpt
- Further research is required to substantiate these specific effects.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (262 words)
ObjectiveThis study conducts a rigorous meta-analysis of existing literature to rigorously examine the efficacy of Proprioceptive Neuromuscular Facilitation (PNF) in ameliorating functional deficits associated with Chronic Ankle Instability (CAI).MethodsLiterature searches were conducted in multiple databases including China National Knowledge Infrastructure (CNKI), VIP, Wanfang, China Biology Medicine disc (CBM), PubMed, EBSCO (Medline, CINAHL, SPORTDiscus, and Rehabilitation & Sports Medicine Source), Embase, ScienceDirect, ProQuest, Cochrane Library, and Web of Science for randomized controlled trials assessing the effects of Proprioceptive Neuromuscular Facilitation interventions on patients with Chronic Ankle Instability. The publication timeframe spanned from the inception of each database until April 10, 2024. Meta-analysis was performed using STATA 12 software on the included studies.Results① A total of 12 randomized controlled trials were included, encompassing 405 patients with Chronic Ankle Instability, demonstrating a generally high methodological quality of the literature.② Meta-analysis results indicate that compared to the control group, Proprioceptive Neuromuscular Facilitation (PNF) significantly enhanced the balance ability of patients with Chronic Ankle Instability as measured by the Y Balance Test (YBT) (Weighted Mean Difference (WMD) = 3.61, 95% CI [2.65, 4.56], z = 7.42, P0.05), however, the effects of PNF training persisted for a certain period even after cessation of treatment.ConclusionProprioceptive Neuromuscular Facilitation (PNF) can significantly improve balance, muscle strength, and pain in patients with Chronic Ankle Instability (CAI). While PNF has shown improvements in joint position sense and dorsiflexion range of motion for CAI patients, with effects that remain for a period thereafter, these improvements were not significantly different when compared to the control group. Further research is required to substantiate these specific effects.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 39787087 · DOI · PMC11717224
Effectiveness of exercise therapy on chronic ankle instability: a meta-analysis [2]
Abstract reading summary — source excerpts
- Opening excerpt
- Lateral ankle sprains are one of the most common musculoskeletal injuries.
- Closing excerpt
- This approach holds significant theoretical and practical value for optimizing CAI treatment strategies and enhancing patient outcomes.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (360 words)
Lateral ankle sprains are one of the most common musculoskeletal injuries. Up to 70% of individuals who sustain lateral ankle sprains develop chronic ankle instability (CAI). Exercise therapy is considered an effective treatment for patients with CAI. This meta-analysis investigated the efficacy of exercise therapy in CAI patients by reviewing 15 randomized controlled trials (RCTs) involving 586 participants. Databases including PubMed, EMBASE, Cochrane Library, and Web of Science were searched from inception to September 13, 2024. The Cochrane Risk of Bias Tool was used to assess study quality. Meta-analysis, sensitivity analysis, and publication bias analysis were conducted using RevMan 5.3.0 and Stata 18.0 software. The Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach was applied to evaluate the quality of evidence. Main outcomes were assessed using the Foot and Ankle Ability Measure (FAAM) and the Star Excursion Balance Test (SEBT). The results demonstrated that exercise therapy significantly improved FAAM-S (MD = 7.98, CI: 4.11 to 11.86, p < 0.0001, I² = 30%). Long-term exercise therapy (over 4 weeks) significantly enhanced FAAM-A (MD = 10.95, CI: 6.60 to 15.29, p < 0.00001, I² = 0%) and dynamic balance ability of ankle joint (SBET-A: MD = 4.83, CI: 1.04 to 8.63, p = 0.01, I² = 62%; SEBT-PM: MD = 6.93, CI: 2.37 to 11.48, p = 0.003, I² = 69%; and SEBT-PL: MD = 8.98, CI: 2.66 to 15.29, p = 0.005, I² = 86%). After categorizing by exercise type, the results indicated that strength training was more effective in improving SEBT-PL (MD = 8.15, CI: 6.09 to 10.21, p < 0.00001, I² = 0%), joint mobilization was more effective in improving SEBT-A (MD = 7.65, CI: 4.93 to 10.37, p < 0.00001, I² = 0%), and proprioceptive training was more effective in improving SEBT-PM (MD = 10.46, CI: 5.27 to 15.65, p < 0.0001, I² = 33%). In conclusion, long-term, multifaceted exercise therapy demonstrates superior rehabilitation efficacy for patients with CAI. Personalized treatment plans, informed by SEBT assessment results, should prioritize targeted interventions such as joint mobilization, strength training, or proprioceptive training. This approach holds significant theoretical and practical value for optimizing CAI treatment strategies and enhancing patient outcomes.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 40188228 · DOI · PMC11972327
Impact of specialized fatigue and backhand smash on the ankle biomechanics of female badminton players [3]
Abstract reading summary — source excerpts
- Opening excerpt
- During fatigued conditions, badminton players may experience adverse effects on their ankle joints during smash landings.
- Closing excerpt
- Compared with BRJS, BLJS poses a higher risk of lateral ankle sprains after fatigue.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (349 words)
During fatigued conditions, badminton players may experience adverse effects on their ankle joints during smash landings. In addition, the risk of ankle injury may vary with different landing strategies. This study aimed to investigate the influence of sport-specific fatigue factors and two backhand smash actions on ankle biomechanical indices. Thirteen female badminton players (age: 21.2 ± 1.9 years; height: 167.1 ± 4.1 cm; weight: 57.3 ± 5.1 kg; BMI: 20.54 ± 1.57 kg/m2) participated in this study. An 8-camera Vicon motion capture system and three Kistler force platforms were used to collect kinematic and kinetic data before and after fatigue for backhand rear-court jump smash (BRJS) and backhand lateral jump smash (BLJS). A 2 × 2 repeated measures analysis of variance was employed to analyze the effects of these smash landing actions and fatigue factors on ankle biomechanical parameters. Fatigue significantly affected the ankle-joint plantarflexion and inversion angles at the initial contact (IC) phase (p < 0.05), with both angles increasing substantially post-fatigue. From a kinetic perspective, fatigue considerably influenced the peak plantarflexion and peak inversion moments at the ankle joint, which resulted in a decrease the former and an increase in the latter after fatigue. The two smash landing actions demonstrated different landing strategies, and significant main effects were observed on the ankle plantarflexion angle, inversion angle, peak dorsiflexion/plantarflexion moment, peak inversion/eversion moment, and peak internal rotation moment (p < 0.05). The BLJS landing had a much greater landing inversion angle, peak inversion moment, and peak internal rotation moment compared with BRJS landing. The interaction effects of fatigue and smash actions significantly affected the muscle force of the peroneus longus (PL), with a more pronounced decrease in the force of the PL muscle post-fatigue in the BLJS action(post-hoc < 0.05). This study demonstrated that fatigue and smash actions, specifically BRJS and BLJS, significantly affect ankle biomechanical parameters. After fatigue, both actions showed a notable increase in IC plantarflexion and inversion angles and peak inversion moments, which may elevate the risk of lateral ankle sprains. Compared with BRJS, BLJS poses a higher risk of lateral ankle sprains after fatigue.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 38704481 · DOI · PMC11069527
Mental Health Predictors of Dynamic Balance in Individuals With Chronic Ankle Instability [4]
Abstract reading summary — source excerpts
- Opening excerpt
- BackgroundChronic ankle instability (CAI) is linked to impaired dynamic balance and psychological deficits, potentially hindering optimal rehabilitation outcomes.
- Closing excerpt
- Incorporating mental health assessments into physical rehabilitation may enhance treatment outcomes for individuals with CAI.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (169 words)
BackgroundChronic ankle instability (CAI) is linked to impaired dynamic balance and psychological deficits, potentially hindering optimal rehabilitation outcomes. However, the impact of psychological deficits on dynamic balance has not been explored before. Therefore, the aim of this study is to determine whether mental health factors predict dynamic balance performance in individuals with CAI using the Star Excursion Balance Test (SEBT).MethodsThis is a cross-sectional observational study performed in a university setting. Forty individuals with CAI (17 men, 23 women) participated in this study. Assessments included psychological profiles (kinesiophobia, self-reported mental health, self-efficacy, global mental health, and functional status via FAAM-Sport). Dynamic balance was evaluated using the SEBT composite and directional scores.ResultsMultiple linear regression analyses indicated that the SEBT composite score was significantly predicted by self-efficacy, global mental health and TSK-11, explaining 40% of the variance (F-value = 7.82, p ConclusionsThe findings underscore the importance of psychological factors as key predictors of dynamic balance in CAI. Incorporating mental health assessments into physical rehabilitation may enhance treatment outcomes for individuals with CAI.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 41913085 · DOI · PMC13581079
Key reviews and meta-analyses
The most cited review-type papers among PubMed’s best-match results for this heading, listed with bibliographic details only. Follow the links for the full text and access terms.
- Research article An Updated Model of Chronic Ankle Instability [5]
- Research article The outcome of total ankle replacement: a systematic review and meta-analysis [6]
- Research article Chronic ankle instability is associated with proprioception deficits: A systematic review and meta-analysis [7]
- Research article A systematic review and meta-analysis of the effect of an ankle-foot orthosis on gait biomechanics after stroke [8]
- Research article Acute lateral ankle sprain to chronic ankle instability: a pathway of dysfunction [9]
- Research article Concentric evertor strength differences and functional ankle instability: a meta-analysis [10]
References
- Yin Y, Wang J, Lin Q, Luo Y, Liu Y, Sun J. Effect of proprioceptive neuromuscular facilitation on patients with chronic ankle instability: A systematic review and meta-analysis. . 2025. PMID 39787087 · DOI · PMC11717224
- Zhang C, Luo Z, Wu D, Fei J, Xie T, Su M. Effectiveness of exercise therapy on chronic ankle instability: a meta-analysis. . 2025. PMID 40188228 · DOI · PMC11972327
- He Z, Liu G, Zhang B, Ye B, Zhu H. Impact of specialized fatigue and backhand smash on the ankle biomechanics of female badminton players. . 2024. PMID 38704481 · DOI · PMC11069527
- Jaffri A. Mental Health Predictors of Dynamic Balance in Individuals With Chronic Ankle Instability. . 2026. PMID 41913085 · DOI · PMC13581079
- Hertel J, Corbett RO. An Updated Model of Chronic Ankle Instability. J Athl Train. 2019. PMID 31162943 · DOI · PMC6602403
- Zaidi R, Cro S, Gurusamy K, Siva N, Macgregor A, Henricson A, et al.. The outcome of total ankle replacement: a systematic review and meta-analysis. Bone Joint J. 2013. PMID 24151270 · DOI
- Xue X, Ma T, Li Q, Song Y, Hua Y. Chronic ankle instability is associated with proprioception deficits: A systematic review and meta-analysis. J Sport Health Sci. 2021. PMID 33017672 · DOI · PMC7987558
- Tyson SF, Sadeghi-Demneh E, Nester CJ. A systematic review and meta-analysis of the effect of an ankle-foot orthosis on gait biomechanics after stroke. Clin Rehabil. 2013. PMID 23798747 · DOI
- Miklovic TM, Donovan L, Protzuk OA, Kang MS, Feger MA. Acute lateral ankle sprain to chronic ankle instability: a pathway of dysfunction. Phys Sportsmed. 2018. PMID 29171312 · DOI
- Arnold BL, Linens SW, de la Motte SJ, Ross SE. Concentric evertor strength differences and functional ankle instability: a meta-analysis. J Athl Train. 2009. PMID 19911093 · DOI · PMC2775368
About this article
- Sources
- NLM Medical Subject Headings (definition, synonyms); NCBI PubMed (counts, identifiers); Europe PMC (open-access abstracts and citation counts).
- Verification
- Every reference was resolved against PubMed on 2026-10-31; title, year and DOI matched.
- Review state
- automated source verified; no human expert review has been recorded yet.
- Version
- 1, last updated 2026-10-31.
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Evidence strength
EvidenceHelix's computed view of the study designs behind this topic: how common meta-analyses, randomized trials and reviews are, how recent the literature is, and a plain-language reading. It describes the design mix of the literature. It is not a quality appraisal of any study, and it is not medical advice.