Definition and research guide
This page combines a MeSH definition, publication statistics and selected research abstracts. It is a starting point for reading the literature, not a medical textbook or a systematic evidence review.
Content available: 3 complete abstracts (837 words), 9 references. Full article text is not stored or reproduced here; follow the PMID, DOI or PMC links to read the original sources and their access terms.
Definition
Vertebrae in the region of the lower BACK below the thoracic vertebrae and above the sacral vertebrae.
Definition: NLM Medical Subject Headings (MeSH) scope note (Public domain (U.S. National Library of Medicine); attribution requested). View the MeSH record.
Also known as: Vertebrae, Lumbar.
Where it fits in the MeSH classification
- Broader topics
- Spine
Related concepts
- Vertebrae
- Thoracic Vertebrae
- Sacrum
Research landscape
PubMed indexes 69,525 records tagged with the MeSH heading “Lumbar Vertebrae” (counts retrieved 2026-10-31). 17,040 of them (24.5%) were published from 2020 onward, and the busiest period so far is 2010-2019 with 21,706 records.
Reviews account for 5,325 records (7.7%) and meta-analyses for 1,106. Randomized controlled trials number 2,944 (4.2%) as a share of all records on the topic.
Show the data
| Period | Records |
|---|---|
| through 1999 | 16,602 |
| 2000-2009 | 14,177 |
| 2010-2019 | 21,706 |
| 2020 onward | 17,040 |
Publication-type chart data
| Type | Records | Share |
|---|---|---|
| Reviews | 5,325 | 7.7% |
| Meta-analyses | 1,106 | 1.6% |
| Randomized controlled trials | 2,944 | 4.2% |
Method: PubMed query "Lumbar Vertebrae"[MeSH Terms] with publication-type and date filters, retrieved 2026-10-31.
Reading the evidence in anatomy and physiology
Anatomy describes how body structures are built and physiology describes how they normally work, so most findings here are descriptive or mechanistic rather than evidence about treatment. Much of what is known comes from dissection, imaging, tissue studies and experiments in animals, and measurements in healthy volunteers can differ from those in people with disease or at different ages. Normal ranges vary between individuals and populations. Check whether a result was measured in people or in another species, the age and health of the participants, and the method used.
Evidence from open-access studies
These open-access studies come from PubMed’s best-match results for this heading (papers whose main topic it is), ranked here by citation count, with one recent addition. Each abstract is reproduced in full under its recorded open licence so that you can read the authors’ own words. They illustrate the literature; they are not a systematic summary of it. Citation counts measure attention, not reliability or clinical benefit.
| Study / authors | Year | Source label / design | Europe PMC citations | Licence / source |
|---|---|---|---|---|
| Muscle damage in oblique lumbar interbody fusion and unilateral biportal endoscopic-transforaminal lumbar interbody fusion for single-level lumbar degeneration diseases: retrospective cohort study | 2025 | Research article Design not recorded in structured metadata | 2 | cc by PMID 41830630 · DOI · PMC12988587 |
| Vertebral bone quality in patients with adolescent idiopathic scoliosis | 2026 | Research article Design not recorded in structured metadata | 2 | cc by PMID 42171904 · DOI · PMC13690848 |
| Severity of structural lumbar spinal stenosis does not impact responsiveness to exercise-based rehabilitation | 2026 | Research article Design not recorded in structured metadata | 1 | cc by PMID 42570301 · DOI · PMC13613343 |
Muscle damage in oblique lumbar interbody fusion and unilateral biportal endoscopic-transforaminal lumbar interbody fusion for single-level lumbar degeneration diseases: retrospective cohort study [1]
Abstract reading summary — source excerpts
- Opening excerpt
- BackgroundIatrogenic injury and approach-related complications in lumbar fusion surgery have become significant concerns.
- Closing excerpt
- Therefore, in cases where both procedures are equally appropriate, OLIF is safer and less damaging to muscles and is the first choice for patients.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (205 words)
BackgroundIatrogenic injury and approach-related complications in lumbar fusion surgery have become significant concerns. This study aims to assess the muscle damage with oblique lumbar interbody fusion (OLIF) compared with unilateral biportal endoscopic-transforaminal lumbar interbody fusion (UBE-TLIF). This assessment will guide better clinical surgical choice in lumbar degeneration diseases.MethodsThis was a retrospective study comparing OLIF combined with anterolateral single screw-rod fixation and UBE-TLIF combined with percutaneous pedicle screws under navigation from January 2021 to December 2023. Individuals with single-level degenerative lumbar disease participated in the study. This study compared the baseline and perioperative parameters (blood loss, operation time, and haematological indicators) and clinical outcome (visual analogue scale scores, Japanese Orthopaedic Association scores, fusion rate, and complications). Measurements of the total cross-sectional area of psoas muscles and paraspinal muscles were obtained using regions of interest defined by manual tracing.ResultsThe cohort comprised 192 patients: 112 underwent OLIF (64 female; mean age 65.1 years) and 80 underwent UBE-TLIF (44 female; mean age 64 years). The operation time (P ConclusionWith OLIF there were lower creatine kinase levels, less blood loss, and less damage to paraspinal muscles. Therefore, in cases where both procedures are equally appropriate, OLIF is safer and less damaging to muscles and is the first choice for patients.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 41830630 · DOI · PMC12988587
Vertebral bone quality in patients with adolescent idiopathic scoliosis [2]
Abstract reading summary — source excerpts
- Opening excerpt
- IntroductionIn adolescent idiopathic scoliosis (AIS), the choice of upper and lowest instrumented vertebrae and related complications remain debated.
- Closing excerpt
- Opportunistic assessment of the VBQ score may therefore be particularly useful in male patients with a structural lumbar curve to identify individuals who may benefit from further evaluation of bone quality.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (379 words)
IntroductionIn adolescent idiopathic scoliosis (AIS), the choice of upper and lowest instrumented vertebrae and related complications remain debated. Bone quality is a relevant factor in this context. The vertebral bone quality (VBQ) score has recently been proposed as a radiation-free magnetic resonance imaging (MRI)-based measure of bone quality. However, the role of the VBQ score in AIS and its relationship with the severity of scoliosis characteristics has not yet been explored. We hypothesize that the VBQ score is associated with key features of AIS, including curve type, Cobb angle, lumbar modifier, and thoracic kyphosis.MethodsThis retrospective study included AIS patients who underwent posterior spinal fusion between 2011 and 2025 at a university hospital. The lumbar VBQ score was determined using preoperative MRI, and the Lenke classification was assessed based on preoperative radiographs. To ensure comparability, curve types were categorized based on the flexibility of the lumbar curvature into non-structural (Lenke types 1 and 2) and structural (Lenke types 3 to 6) groups. The association between VBQ and curve type, Cobb angle, lumbar modifier, and thoracic kyphosis-while considering MRI field strength, age, sex, and body mass index (BMI)-was analyzed using multiple linear regression analyses.ResultsThis single-center study included 60 patients (male: 15%, female: 85%) with a median age of 15 years (interquartile range (IQR): 14-16 years) and a median BMI of 18.9 kg/m2 (IQR: 17.5-22.4 kg/m2), diagnosed with AIS presenting with non-structural (55%) and structural (45%) lumbar curves. A significant association was found with lumbar curve flexibility (r2 = 0.298, p = 0.035), indicating that structural lumbar curves correlated with lower bone quality. Additionally, female patients showed significantly better bone quality (r2 = -0.446, p = 0.005). No significant correlation was observed between the VBQ score and Cobb angle (r2 = -0.003, p = 0.370), thoracic kyphosis (r2 = 0.001, p = 0.734), lumbar modifier (r2 = -0.116, p = 0.123), MRI field strength (r2 = -0.181, p = 0.098), age (r2 = 0.018, p = 0.558), or BMI (r2 = -0.014, p = 0.275).ConclusionOur study demonstrated a significant correlation between the VBQ score and both lumbar curve flexibility and sex. Opportunistic assessment of the VBQ score may therefore be particularly useful in male patients with a structural lumbar curve to identify individuals who may benefit from further evaluation of bone quality.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 42171904 · DOI · PMC13690848
Severity of structural lumbar spinal stenosis does not impact responsiveness to exercise-based rehabilitation [3]
Abstract reading summary — source excerpts
- Opening excerpt
- ImportanceSpine pain is a prevalent and costly condition affecting up to 85% of individuals throughout their lifetime, and spinal stenosis is one of the most debilitating sources of spine pain.
- Closing excerpt
- RelevanceExercise-based rehabilitation results in the same magnitude of improvement in individuals with chronic low back pain regardless of radiographic severity of spinal stenosis.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (253 words)
ImportanceSpine pain is a prevalent and costly condition affecting up to 85% of individuals throughout their lifetime, and spinal stenosis is one of the most debilitating sources of spine pain. Although conservative management is the first line of treatment for spinal stenosis, radiographically severe cases often are directly referred to surgical intervention due to the belief that conservative strategies delay necessary treatment. However, no studies support the premise that individuals with more radiographically severe stenosis respond poorly to conservative management.ObjectiveThe purpose of this study was to compare improvements in pain, disability, strength, medication usage, and patient function after an exercise-based physical therapist-led program.DesignThis study was a retrospective analysis of a single arm clinical trial.SettingThis was in the setting of an outpatient exercise-based physical therapist-led program.ParticipantsOne thousand eight hundred six individuals with radiographically mild, moderate, or severe lumbar spine stenosis participated in this study.InterventionThe intervention was an exercise-based physical therapist-led program.Outcomes and measuresOutcome measures included pain, low back pain related disability, patient specific function, analgesic medication use, and lumbar extensor strength.ResultsParticipants demonstrated significant improvements in all variables of interest, and 11.5% of participants reported cessation of narcotic use with treatment. There were no significant differences in treatment response across radiographically mild, moderate, or severe stenosis groups for any outcome.ConclusionsExercise-based rehabilitation is as beneficial in the short term for individuals presenting for nonoperative care with radiographically severe stenosis compared to their milder counterparts.RelevanceExercise-based rehabilitation results in the same magnitude of improvement in individuals with chronic low back pain regardless of radiographic severity of spinal stenosis.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 42570301 · DOI · PMC13613343
Key reviews and meta-analyses
The most cited review-type papers among PubMed’s best-match results for this heading, listed with bibliographic details only. Follow the links for the full text and access terms.
- Research article Dietary protein and bone health: a systematic review and meta-analysis from the National Osteoporosis Foundation [4]
- Research article Anterior lumbar interbody fusion versus transforaminal lumbar interbody fusion--systematic review and meta-analysis [5]
- Research article Minimally Invasive Versus Open Laminectomy for Lumbar Stenosis: A Systematic Review and Meta-Analysis [6]
- Research article Lumbar Neuraxial Ultrasound for Spinal and Epidural Anesthesia: A Systematic Review and Meta-Analysis [7]
- Research article Minimally invasive versus open transforaminal lumbar interbody fusion for treatment of degenerative lumbar disease: systematic review and meta-analysis [8]
- Research article Surgical Outcomes for Minimally Invasive vs Open Transforaminal Lumbar Interbody Fusion: An Updated Systematic Review and Meta-analysis [9]
References
- Chen T, Wang X, Li R, Yang S, Li X, Zhu Y, et al.. Muscle damage in oblique lumbar interbody fusion and unilateral biportal endoscopic-transforaminal lumbar interbody fusion for single-level lumbar degeneration diseases: retrospective cohort study. . 2025. PMID 41830630 · DOI · PMC12988587
- Hoehl BU, Becker L, Li Z, Wang Z, Schmidt H, Pumberger M, et al.. Vertebral bone quality in patients with adolescent idiopathic scoliosis. . 2026. PMID 42171904 · DOI · PMC13690848
- Shahidi B, Zavareh A, Richards C, Taitano L, Raiszadeh K. Severity of structural lumbar spinal stenosis does not impact responsiveness to exercise-based rehabilitation. . 2026. PMID 42570301 · DOI · PMC13613343
- Shams-White MM, Chung M, Du M, Fu Z, Insogna KL, Karlsen MC, et al.. Dietary protein and bone health: a systematic review and meta-analysis from the National Osteoporosis Foundation. Am J Clin Nutr. 2017. PMID 28404575 · DOI
- Phan K, Thayaparan GK, Mobbs RJ. Anterior lumbar interbody fusion versus transforaminal lumbar interbody fusion--systematic review and meta-analysis. Br J Neurosurg. 2015. PMID 25968330 · DOI
- Phan K, Mobbs RJ. Minimally Invasive Versus Open Laminectomy for Lumbar Stenosis: A Systematic Review and Meta-Analysis. Spine (Phila Pa 1976). 2016. PMID 26555839 · DOI
- Perlas A, Chaparro LE, Chin KJ. Lumbar Neuraxial Ultrasound for Spinal and Epidural Anesthesia: A Systematic Review and Meta-Analysis. Reg Anesth Pain Med. 2016. PMID 25493689 · DOI
- Phan K, Rao PJ, Kam AC, Mobbs RJ. Minimally invasive versus open transforaminal lumbar interbody fusion for treatment of degenerative lumbar disease: systematic review and meta-analysis. Eur Spine J. 2015. PMID 25813010 · DOI
- Khan NR, Clark AJ, Lee SL, Venable GT, Rossi NB, Foley KT. Surgical Outcomes for Minimally Invasive vs Open Transforaminal Lumbar Interbody Fusion: An Updated Systematic Review and Meta-analysis. Neurosurgery. 2015. PMID 26214320 · DOI
About this article
- Sources
- NLM Medical Subject Headings (definition, synonyms); NCBI PubMed (counts, identifiers); Europe PMC (open-access abstracts and citation counts).
- Verification
- Every reference was resolved against PubMed on 2026-10-31; title, year and DOI matched.
- Review state
- automated source verified; no human expert review has been recorded yet.
- Version
- 1, last updated 2026-10-31.
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Evidence strength
EvidenceHelix's computed view of the study designs behind this topic: how common meta-analyses, randomized trials and reviews are, how recent the literature is, and a plain-language reading. It describes the design mix of the literature. It is not a quality appraisal of any study, and it is not medical advice.